Antibody-dependent cellular phagocytosis in antiviral immune responses

MZ Tay, K Wiehe, J Pollara - Frontiers in immunology, 2019‏ - frontiersin.org
Antiviral activities of antibodies may either be dependent only on interactions between the
antibody and cognate antigen, as in binding and neutralization of an infectious virion, or …

HIV prevention transformed: the new prevention research agenda

NS Padian, SI McCoy, SSA Karim, N Hasen, J Kim… - The Lancet, 2011‏ - thelancet.com
We have entered a new era in HIV prevention whereby priorities have expanded from
biomedical discovery to include implementation, effectiveness, and the effect of combination …

A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP. 664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing …

RW Sanders, R Derking, A Cupo, JP Julien… - PLoS …, 2013‏ - journals.plos.org
A desirable but as yet unachieved property of a human immunodeficiency virus type 1 (HIV-
1) vaccine candidate is the ability to induce broadly neutralizing antibodies (bNAbs). One …

Immune-correlates analysis of an HIV-1 vaccine efficacy trial

BF Haynes, PB Gilbert, MJ McElrath… - … England Journal of …, 2012‏ - Mass Medical Soc
Background In the RV144 trial, the estimated efficacy of a vaccine regimen against human
immunodeficiency virus type 1 (HIV-1) was 31.2%. We performed a case–control analysis to …

Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG

GD Tomaras, G Ferrari, X Shen, SM Alam… - Proceedings of the …, 2013‏ - pnas.org
Analysis of correlates of risk of infection in the RV144 HIV-1 vaccine efficacy trial
demonstrated that plasma IgG against the HIV-1 envelope (Env) variable region 1 and 2 …

Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2

HX Liao, M Bonsignori, SM Alam, JS McLellan… - Immunity, 2013‏ - cell.com
The RV144 HIV-1 trial of the canary pox vector (ALVAC-HIV) plus the gp120 AIDSVAX B/E
vaccine demonstrated an estimated efficacy of 31%, which correlated directly with …

Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial target multiple epitopes and preferentially use the VH1 gene family

M Bonsignori, J Pollara, MA Moody, MD Alpert… - Journal of …, 2012‏ - journals.asm.org
ABSTRACT The ALVAC-HIV/AIDSVAX-B/E RV144 vaccine trial showed an estimated
efficacy of 31%. RV144 secondary immune correlate analysis demonstrated that the …

Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys

DH Barouch, J Liu, H Li, LF Maxfield, P Abbink… - Nature, 2012‏ - nature.com
Preclinical studies of human immunodeficiency virus type 1 (HIV-1) vaccine candidates have
typically shown post-infection virological control, but protection against acquisition of …

A yeast-expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates

M Pino, T Abid, S Pereira Ribeiro, VV Edara… - Science …, 2021‏ - science.org
Ongoing severe acute respiratory syndrome coronavirus–2 (SARS-CoV-2) vaccine
development is focused on identifying stable, cost-effective, and accessible candidates for …

[HTML][HTML] Vaccine-induced protection from homologous tier 2 SHIV challenge in nonhuman primates depends on serum-neutralizing antibody titers

MG Pauthner, JP Nkolola, C Havenar-Daughton… - Immunity, 2019‏ - cell.com
Passive administration of HIV neutralizing antibodies (nAbs) can protect macaques from
hard-to-neutralize (tier 2) chimeric simian-human immunodeficiency virus (SHIV) challenge …