Bruton's tyrosine kinase (BTK) is a non-receptor kinase that plays a crucial role in oncogenic
signaling that is critical for proliferation and survival of leukemic cells in many B cell …

Bruton's tyrosine kinase (BTK) is a key component of B cell receptor (BCR) signalling and
functions as an important regulator of cell proliferation and cell survival in various B cell …

The process by which extracellular signals are relayed from the plasma membrane to
specific intracellular sites is an essential facet of cellular regulation. Many signaling …

Loss of function of the phosphatase and tensin homolog deleted on chromosome 10 (PTEN)
tumor suppressor gene is associated with many human cancers. In the cytoplasm, PTEN …

We report the results of a multicenter phase 1 dose-escalation study of the selective Bruton
tyrosine kinase (BTK) inhibitor ONO/GS-4059 in 90 patients with relapsed/refractory B-cell …

▪ Abstract The 3-phosphorylated inositol lipids fulfill roles as second messengers by
interacting with the lipid binding domains of a variety of cellular proteins. Such interactions …

Zinc is known to be indispensable to growth and development and transmission of the
genetic message. It does this through a remarkable mosaic of zinc binding motifs that …

Bruton's agammaglobulinemia tyrosine kinase (Btk) is a cytoplasmic tyrosine kinase
important in B‐lymphocyte development, differentiation, and signaling. Btk is a member of …

The protein kinase encoded by the Akt proto-oncogene is activated by phospholipid binding,
membrane translocation and phosphorylation. To address the relative roles of these …

Pleckstrin homology (PH) domains are small protein modules of around 120 amino acids
found in many proteins involved in cell signalling, cytoskeletal rearrangement and other …