On the biomechanics of heart valve function

MS Sacks, WD Merryman, DE Schmidt - Journal of biomechanics, 2009 - Elsevier
Heart valves (HVs) are fluidic control components of the heart that ensure unidirectional
blood flow during the cardiac cycle. However, this description does not adequately describe …

Heart valve function: a biomechanical perspective

MS Sacks, AP Yoganathan - … Transactions of the Royal …, 2007 - royalsocietypublishing.org
Heart valves (HVs) are cardiac structures whose physiological function is to ensure directed
blood flow through the heart over the cardiac cycle. While primarily passive structures that …

Experimental investigation of collagen waviness and orientation in the arterial adventitia using confocal laser scanning microscopy

R Rezakhaniha, A Agianniotis, JTC Schrauwen… - … and modeling in …, 2012 - Springer
Mechanical properties of the adventitia are largely determined by the organization of
collagen fibers. Measurements on the waviness and orientation of collagen, particularly at …

Accordion-like honeycombs for tissue engineering of cardiac anisotropy

GC Engelmayr Jr, M Cheng, CJ Bettinger… - Nature materials, 2008 - nature.com
Tissue-engineered grafts may be useful in myocardial repair; however, previous scaffolds
have been structurally incompatible with recapitulating cardiac anisotropy. Here, we use …

Biaxial mechanical evaluation of planar biological materials

MS Sacks - Journal of elasticity and the physical science of solids, 2000 - Springer
A fundamental goal in constitutive modeling is to predict the mechanical behavior of a
material under a generalized loading state. To achieve this goal, rigorous experimentation …

Percutaneously implantable replacement heart valve device and method of making same

D Paniagua, E Induni, C Mejia… - US Patent …, 2012 - Google Patents
L. Yaskanin (65) Prior Publication Data US 2005/O11391. 0 A1 May 26, 2005(57)
ABSTRACT The present invention comprises a percutaneously implant Related US …

Biaxial mechanical properties of the natural and glutaraldehyde treated aortic valve cusp—part I: experimental results

KL Billiar, MS Sacks - J. Biomech. Eng., 2000 - asmedigitalcollection.asme.org
To date, there are no constitutive models for either the natural or bioprosthetic aortic valve
(AV), in part due to experimental complications related to the AV's small size and …

[HTML][HTML] Bioinspired heart valve prosthesis made by silicone additive manufacturing

FB Coulter, M Schaffner, JA Faber, A Rafsanjani… - Matter, 2019 - cell.com
Synthetic implants made by traditional fabrication routes are not patient specific and rarely
match the performance of their biological counterparts. We present an additive …

Incorporation of experimentally-derived fiber orientation into a structural constitutive model for planar collagenous tissues

MS Sacks - J. Biomech. Eng., 2003 - asmedigitalcollection.asme.org
Structural constitutive models integrate information on tissue composition and structure,
avoiding ambiguities in material characterization. However, critical structural information …

Effects of decellularization on the mechanical and structural properties of the porcine aortic valve leaflet

J Liao, EM Joyce, MS Sacks - Biomaterials, 2008 - Elsevier
The potential for decellularized aortic heart valves (AVs) as heart valve replacements is
based on the assumption that the major cellular immunogenic components have been …