Applications of single-cell RNA sequencing in drug discovery and development
B Van de Sande, JS Lee, E Mutasa-Gottgens… - Nature Reviews Drug …, 2023 - nature.com
Single-cell technologies, particularly single-cell RNA sequencing (scRNA-seq) methods,
together with associated computational tools and the growing availability of public data …
together with associated computational tools and the growing availability of public data …
Map** epigenetic modifications by sequencing technologies
X Chen, H Xu, X Shu, CX Song - Cell Death & Differentiation, 2025 - nature.com
The “epigenetics” concept was first described in 1942. Thus far, chemical modifications on
histones, DNA, and RNA have emerged as three important building blocks of epigenetic …
histones, DNA, and RNA have emerged as three important building blocks of epigenetic …
Dictionary learning for integrative, multimodal and scalable single-cell analysis
Map** single-cell sequencing profiles to comprehensive reference datasets provides a
powerful alternative to unsupervised analysis. However, most reference datasets are …
powerful alternative to unsupervised analysis. However, most reference datasets are …
MOFA+: a statistical framework for comprehensive integration of multi-modal single-cell data
Technological advances have enabled the profiling of multiple molecular layers at single-
cell resolution, assaying cells from multiple samples or conditions. Consequently, there is a …
cell resolution, assaying cells from multiple samples or conditions. Consequently, there is a …
Multi-omics profiling of mouse gastrulation at single-cell resolution
Formation of the three primary germ layers during gastrulation is an essential step in the
establishment of the vertebrate body plan and is associated with major transcriptional …
establishment of the vertebrate body plan and is associated with major transcriptional …
High-throughput single-cell ChIP-seq identifies heterogeneity of chromatin states in breast cancer
K Grosselin, A Durand, J Marsolier, A Poitou… - Nature …, 2019 - nature.com
Modulation of chromatin structure via histone modification is a major epigenetic mechanism
and regulator of gene expression. However, the contribution of chromatin features to tumor …
and regulator of gene expression. However, the contribution of chromatin features to tumor …
scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells
Parallel single-cell sequencing protocols represent powerful methods for investigating
regulatory relationships, including epigenome-transcriptome interactions. Here, we report a …
regulatory relationships, including epigenome-transcriptome interactions. Here, we report a …
Map** the epigenetic modifications of DNA and RNA
Over 17 and 160 types of chemical modifications have been identified in DNA and RNA,
respectively. The interest in understanding the various biological functions of DNA and RNA …
respectively. The interest in understanding the various biological functions of DNA and RNA …
Ultrafast bisulfite sequencing detection of 5-methylcytosine in DNA and RNA
Bisulfite sequencing (BS-seq) to detect 5-methylcytosine (5mC) is limited by lengthy reaction
times, severe DNA damage, overestimation of 5mC level and incomplete C-to-U conversion …
times, severe DNA damage, overestimation of 5mC level and incomplete C-to-U conversion …
scEpiAge: an age predictor highlighting single-cell ageing heterogeneity in mouse blood
Ageing is the accumulation of changes and decline of function of organisms over time. The
concept and biomarkers of biological age have been established, notably DNA methylation …
concept and biomarkers of biological age have been established, notably DNA methylation …