The physical continuity of axons over long cellular distances poses challenges for their
maintenance. One organelle that faces this challenge is endoplasmic reticulum (ER); unlike …

The various splice variants of the three SERCA-and the two SPCA-pump genes in higher
vertebrates encode P-type ATPases of the P2A group found respectively in the membranes …

Although the genetic basis of many kidney diseases is being rapidly elucidated, their
experimental study remains problematic owing to the lack of suitable models. The fruitfly …

Over the past decade the adoption and refinement of the GAL4 system by the Drosophila
field has resulted in a wide array of tools with which the researcher can drive transgene …

Reactive oxygen species (ROS)/reactive nitrogen species (RNS) and ROS/RNS-mediated
oxidative stress have well-established roles in many physiological and pathological …

In recent years, much progress has been made with respect to the unravelling of the
functions of peroxisomes in metabolism, and it is now well established that peroxisomes are …

The insect excretory system contains two organ systems acting in concert: the Malpighian
tubules and the hindgut perform essential roles in excretion and ionic and osmotic …

Highlights•Metal ions play multiple roles in osmoregulation and homeostasis.•Many metals
are cofactors of metalloenzymes.•Ion balance underpins environmental resilience, for …

Overexposure to manganese disrupts cellular energy metabolism across species, but the
molecular mechanism underlying manganese toxicity remains enigmatic. Here, we report …

The evolution of specialized excretory cells is a cornerstone of the metazoan radiation, and
the basic tasks performed by Drosophila and human renal systems are similar. The …