Phytochemicals against TNFα-Mediated Neuroinflammatory Diseases

L Subedi, SE Lee, S Madiha, BP Gaire, M **… - International journal of …, 2020 - mdpi.com
Tumor necrosis factor-alpha (TNF-α) is a well-known pro-inflammatory cytokine responsible
for the modulation of the immune system. TNF-α plays a critical role in almost every type of …

[HTML][HTML] Kava as a clinical nutrient: promises and challenges

T Bian, P Corral, Y Wang, J Botello, R Kingston… - Nutrients, 2020 - mdpi.com
Kava beverages are typically prepared from the root of Piper methysticum. They have been
consumed among Pacific Islanders for centuries. Kava extract preparations were once used …

Dietary supplementation of gingerols-and shogaols-enriched ginger root extract attenuate pain-associated behaviors while modulating gut microbiota and metabolites …

CL Shen, R Wang, G Ji, MM Elmassry… - The Journal of nutritional …, 2022 - Elsevier
Neuroinflammation is a central factor in neuropathic pain (NP). Ginger is a promising
bioactive compound in NP management due to its anti-inflammatory property. Emerging …

[HTML][HTML] Oral administration of methysticin improves cognitive deficits in a mouse model of Alzheimer's disease

A Fragoulis, S Siegl, M Fendt, S Jansen, U Soppa… - Redox biology, 2017 - Elsevier
Introduction There is increasing evidence for the involvement of chronic inflammation and
oxidative stress in the pathogenesis of Alzheimer's disease (AD). Nuclear factor erythroid 2 …

Opportunities and challenges of kava in lung cancer prevention

B Freeman, J Mamallapalli, T Bian, K Ballas… - International journal of …, 2023 - mdpi.com
Lung cancer is the leading cause of cancer-related deaths due to its high incidence, late
diagnosis, and limited success in clinical treatment. Prevention therefore is critical to help …

Whole-body deletion of LPS-induced TNF-α factor (LITAF) markedly improves experimental endotoxic shock and inflammatory arthritis

JC Merrill, J You, C Constable, SE Leeman… - Proceedings of the …, 2011 - pnas.org
LPS-induced TNF-α factor (LITAF) mediates cytokine expression in response to endotoxin
challenge. Previously, we reported that macrophage-specific LITAF-deficient (macLITAF−/−) …

Phytochemicals as a potential source for TNF-α inhibitors

M Iqbal, R Verpoorte, HAAJ Korthout… - Phytochemistry Reviews, 2013 - Springer
Cytokines play an important role in the immune system. Any disorder in the regulation of
cytokines can lead to the development of inflammatory diseases. Tumor necrosis factor-α …

Biological Activity, Hepatotoxicity, and Structure‐Activity Relationship of Kavalactones and Flavokavins, the Two Main Bioactive Components in Kava (Piper …

Y Wang, C Su, B Zhang, Y Niu, R Ren… - Evidence‐Based …, 2021 - Wiley Online Library
Kava (Piper methysticum Forst) is a popular and favorable edible medicinal herb which was
traditionally used to prepare a nonfermented beverage with relaxant beneficial for both …

Receptor activator of nuclear factor kappa B ligand antagonists inhibit tissue inflammation and bone loss in experimental periodontitis

H Yuan, R Gupte, S Zelkha… - Journal of clinical …, 2011 - Wiley Online Library
Aim The purpose of this study was to assess the role of anti‐bone resorptive agents and an
anti‐inflammatory compound in murine Porphyromonas gingivalis (P. gingivalis)‐induced …

Secondary metabolites and biological properties of Gesneriaceae species

MH Verdan, MÉA Stefanello - Chemistry & biodiversity, 2012 - Wiley Online Library
The family Gesneriaceae comprises ca. 150 genera and 3000 species, distributed in the
tropics around the world. It is constituted of herbs, lianas, or shrubs, frequently with …