The evolution of poxvirus vaccines
After Edward Jenner established human vaccination over 200 years ago, attenuated
poxviruses became key players to contain the deadliest virus of its own family: Variola virus …
poxviruses became key players to contain the deadliest virus of its own family: Variola virus …
Human cytomegalovirus: taking the strain
In celebrating the 60th anniversary of the first isolation of human cytomegalovirus (HCMV),
we reflect on the merits and limitations of the viral strains currently being used to develop …
we reflect on the merits and limitations of the viral strains currently being used to develop …
[HTML][HTML] Multi-antigenic human cytomegalovirus mRNA vaccines that elicit potent humoral and cell-mediated immunity
A cytomegalovirus (CMV) vaccine that is effective at preventing congenital infection and
reducing CMV disease in transplant patients remains a high priority as no approved …
reducing CMV disease in transplant patients remains a high priority as no approved …
Development of a multi-antigenic SARS-CoV-2 vaccine candidate using a synthetic poxvirus platform
F Chiuppesi, MA Salazar, H Contreras… - Nature …, 2020 - nature.com
Abstract Modified Vaccinia Ankara (MVA) is a highly attenuated poxvirus vector that is widely
used to develop vaccines for infectious diseases and cancer. We demonstrate the …
used to develop vaccines for infectious diseases and cancer. We demonstrate the …
HCMV glycoprotein B subunit vaccine efficacy mediated by nonneutralizing antibody effector functions
Human cytomegalovirus (HCMV) is the most common congenital infection worldwide,
frequently causing hearing loss and brain damage in afflicted infants. A vaccine to prevent …
frequently causing hearing loss and brain damage in afflicted infants. A vaccine to prevent …
Synthetic multiantigen MVA vaccine COH04S1 protects against SARS-CoV-2 in Syrian hamsters and non-human primates
Second-generation COVID-19 vaccines could contribute to establish protective immunity
against SARS-CoV-2 and its emerging variants. We developed COH04S1, a synthetic …
against SARS-CoV-2 and its emerging variants. We developed COH04S1, a synthetic …
Modeling human cytomegalovirus-induced microcephaly in human iPSC-derived brain organoids
Although congenital infection by human cytomegalovirus (HCMV) is well recognized as a
leading cause of neurodevelopmental defects, HCMV neuropathogenesis remains poorly …
leading cause of neurodevelopmental defects, HCMV neuropathogenesis remains poorly …
Cytomegalovirus vaccines: current status and future prospects
Congenital human cytomegalovirus (HCMV) infection can result in severe and permanent
neurological injury in newborns, and vaccine development is accordingly a major public …
neurological injury in newborns, and vaccine development is accordingly a major public …
Progress toward development of a vaccine against congenital cytomegalovirus infection
ABSTRACT A vaccine against congenital human cytomegalovirus (CMV) infection is a major
public health priority. Congenital CMV causes substantial long-term morbidity, particularly …
public health priority. Congenital CMV causes substantial long-term morbidity, particularly …
Protective capacity of neutralizing and non-neutralizing antibodies against glycoprotein B of cytomegalovirus
A Bootz, A Karbach, J Spindler, B Kropff… - PLoS …, 2017 - journals.plos.org
Human cytomegalovirus (HCMV) is an important, ubiquitous pathogen that causes severe
clinical disease in immunocompromised individuals, such as organ transplant recipients and …
clinical disease in immunocompromised individuals, such as organ transplant recipients and …