Antibiotic-mediated perturbation of the gut microbiome is associated with numerous infectious and autoimmune diseases of the gastrointestinal tract. Yet, as the gut microbiome …
Prenatal and early postnatal life represent key periods of immune system development. In addition to genetics and host biology, environment has a large and irreversible role in the …
Maternal microbiota forms the first infant gut microbial inoculum, and perinatal factors (diet and use of antibiotics during pregnancy) and/or neonatal factors, like intra partum antibiotics …
Antibiotic exposure at the beginning of life can lead to increased antimicrobial resistance and perturbations of the develo** microbiome. Early-life microbiome disruption increases …
Background Early antibiotic exposure is linked to persistent disruption of the infant gut microbiome and subsequent elevated pediatric asthma risk. Breastfeeding acts as a primary …
O Perdijk, A Butler, M Macowan, R Chatzis, E Bulanda… - Immunity, 2024 - cell.com
Antibiotic use in early life disrupts microbial colonization and increases the risk of develo** allergies and asthma. We report that mice given antibiotics in early life (EL-Abx) …
KE Hays, JM Pfaffinger, R Ryznar - Gut Microbes, 2024 - Taylor & Francis
Short-chain fatty acids (SCFAs)–acetate, propionate, and butyrate–are important bacterial fermentation metabolites regulating many important aspects of human physiology …
The last decade of microbiome research has highlighted its fundamental role in systemic immune and metabolic homeostasis. The microbiome plays a prominent role during …
Background Inappropriate antimicrobial usage is a key driver of antimicrobial resistance (AMR). Low-and middle-income countries (LMICs) are disproportionately burdened by AMR …
D Mascarenhas, MSP Ho, J Ting, PS Shah - Pediatrics, 2024 - publications.aap.org
Video Abstract BACKGROUND AND OBJECTIVES Neonatal sepsis is a significant contributor to mortality and morbidity; however, the uncontrolled use of antimicrobials is …