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Establishing electron diffraction in chemical crystallography
T Gruene, JJ Holstein, GH Clever… - Nature Reviews Chemistry, 2021 - nature.com
The emerging field of 3D electron diffraction (3D ED) opens new opportunities for structure
determination from sub-micrometre-sized crystals. Although the foundations of this …
determination from sub-micrometre-sized crystals. Although the foundations of this …
Electron diffraction of 3D molecular crystals
Electron crystallography has a storied history which rivals that of its more established X-ray-
enabled counterpart. Recent advances in data collection and analysis have sparked a …
enabled counterpart. Recent advances in data collection and analysis have sparked a …
Alternating heterochiral supramolecular copolymerization
In stacking-based supramolecular polymerization, chiral hydrogen bonding (H-bonding)
monomers often prefer to adapt a homochiral monomer sequence. Herein, we investigated …
monomers often prefer to adapt a homochiral monomer sequence. Herein, we investigated …
The Elusive Structure of Levocetirizine Dihydrochloride Determined by Electron Diffraction
Levocetirizine is an orally administrated, second‐generation antihistaminic active
pharmaceutical ingredient that has been used to treat symptoms of allergy and long‐term …
pharmaceutical ingredient that has been used to treat symptoms of allergy and long‐term …
Electron diffraction and solid-state NMR reveal the structure and exciton coupling in a eumelanin precursor
Eumelanin, a versatile biomaterial found throughout the animal kingdom, performs essential
functions like photoprotection and radical scavenging. The diverse properties of eumelanin …
functions like photoprotection and radical scavenging. The diverse properties of eumelanin …
Microcrystal electron diffraction (MicroED) structure determination of a mechanochemically synthesized co-crystal not affordable from solution crystallization
Solid-state grinding can provide “mechano-distinctive” co-crystals that are not accessible
from solutions. Herein, we demonstrate the structure determination of a powdered mechano …
from solutions. Herein, we demonstrate the structure determination of a powdered mechano …
Solvent effect on molecular conformational evolution and polymorphic manipulation of cimetidine
In the field of pharmaceutical crystallization, the success of polymorphic manipulation is vital
to the performance of pharmaceutical formulations, and the choice of solvents might affect …
to the performance of pharmaceutical formulations, and the choice of solvents might affect …
Organic NMR crystallography: enabling progress for applications to pharmaceuticals and plant cell walls
The application of NMR crystallography to organic molecules is exemplified by two case
studies. For the tosylate salt of the active pharmaceutical ingredient, Ritlectinib, solid-state …
studies. For the tosylate salt of the active pharmaceutical ingredient, Ritlectinib, solid-state …
Solid-state NMR spectroscopy for the analysis of element-based non-covalent interactions
We review applications of solid-state NMR spectroscopy for the analysis of element-based
non-covalent interactions, with an emphasis on developments since 2009. The review is …
non-covalent interactions, with an emphasis on developments since 2009. The review is …
B/N-Doped p-Arylenevinylene Chromophores: Synthesis, Properties, and Microcrystal Electron Crystallographic Study
Linearly conjugated systems have long served as an archetype of conjugated materials, but
suffer from two intrinsic structural problems: potential instability due to intermolecular …
suffer from two intrinsic structural problems: potential instability due to intermolecular …