Establishing electron diffraction in chemical crystallography

T Gruene, JJ Holstein, GH Clever… - Nature Reviews Chemistry, 2021 - nature.com
The emerging field of 3D electron diffraction (3D ED) opens new opportunities for structure
determination from sub-micrometre-sized crystals. Although the foundations of this …

Electron diffraction of 3D molecular crystals

A Saha, SS Nia, JA Rodríguez - Chemical Reviews, 2022 - ACS Publications
Electron crystallography has a storied history which rivals that of its more established X-ray-
enabled counterpart. Recent advances in data collection and analysis have sparked a …

Alternating heterochiral supramolecular copolymerization

M Ueda, T Aoki, T Akiyama, T Nakamuro… - Journal of the …, 2021 - ACS Publications
In stacking-based supramolecular polymerization, chiral hydrogen bonding (H-bonding)
monomers often prefer to adapt a homochiral monomer sequence. Herein, we investigated …

The Elusive Structure of Levocetirizine Dihydrochloride Determined by Electron Diffraction

DP Karothu, Z Alhaddad, CR Göb… - Angewandte Chemie …, 2023 - Wiley Online Library
Levocetirizine is an orally administrated, second‐generation antihistaminic active
pharmaceutical ingredient that has been used to treat symptoms of allergy and long‐term …

Electron diffraction and solid-state NMR reveal the structure and exciton coupling in a eumelanin precursor

K Vinod, R Mathew, C Jandl, B Thomas… - Chemical Science, 2024 - pubs.rsc.org
Eumelanin, a versatile biomaterial found throughout the animal kingdom, performs essential
functions like photoprotection and radical scavenging. The diverse properties of eumelanin …

Microcrystal electron diffraction (MicroED) structure determination of a mechanochemically synthesized co-crystal not affordable from solution crystallization

T Sasaki, T Nakane, A Kawamoto, T Nishizawa… - …, 2023 - pubs.rsc.org
Solid-state grinding can provide “mechano-distinctive” co-crystals that are not accessible
from solutions. Herein, we demonstrate the structure determination of a powdered mechano …

Solvent effect on molecular conformational evolution and polymorphic manipulation of cimetidine

B Tian, H Hao, X Huang, T Wang, J Wang… - Crystal Growth & …, 2023 - ACS Publications
In the field of pharmaceutical crystallization, the success of polymorphic manipulation is vital
to the performance of pharmaceutical formulations, and the choice of solvents might affect …

Organic NMR crystallography: enabling progress for applications to pharmaceuticals and plant cell walls

Z Rehman, J Lubay, WT Franks, AP Bartók… - Faraday …, 2025 - pubs.rsc.org
The application of NMR crystallography to organic molecules is exemplified by two case
studies. For the tosylate salt of the active pharmaceutical ingredient, Ritlectinib, solid-state …

Solid-state NMR spectroscopy for the analysis of element-based non-covalent interactions

Y Xu, PMJ Szell, V Kumar, DL Bryce - Coordination Chemistry Reviews, 2020 - Elsevier
We review applications of solid-state NMR spectroscopy for the analysis of element-based
non-covalent interactions, with an emphasis on developments since 2009. The review is …

B/N-Doped p-Arylenevinylene Chromophores: Synthesis, Properties, and Microcrystal Electron Crystallographic Study

H Lu, T Nakamuro, K Yamashita… - Journal of the …, 2020 - ACS Publications
Linearly conjugated systems have long served as an archetype of conjugated materials, but
suffer from two intrinsic structural problems: potential instability due to intermolecular …