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CD8+ T cells in the cancer-immunity cycle
CD8+ T cells are end effectors of cancer immunity. Most forms of effective cancer
immunotherapy involve CD8+ T cell effector function. Here, we review the current …
immunotherapy involve CD8+ T cell effector function. Here, we review the current …
Immune checkpoint therapy for solid tumours: clinical dilemmas and future trends
Q Sun, Z Hong, C Zhang, L Wang, Z Han… - Signal transduction and …, 2023 - nature.com
Abstract Immune-checkpoint inhibitors (ICBs), in addition to targeting CTLA-4, PD-1, and PD-
L1, novel targeting LAG-3 drugs have also been approved in clinical application. With the …
L1, novel targeting LAG-3 drugs have also been approved in clinical application. With the …
T cell exhaustion
T cell responses must be balanced to ensure adequate protection against malignant
transformation and an array of pathogens while also limiting damage to healthy cells and …
transformation and an array of pathogens while also limiting damage to healthy cells and …
Stereotactic ablative radiotherapy with or without immunotherapy for early-stage or isolated lung parenchymal recurrent node-negative non-small-cell lung cancer: an …
JY Chang, SH Lin, W Dong, Z Liao, SJ Gandhi, CM Gay… - The Lancet, 2023 - thelancet.com
Background Stereotactic ablative radiotherapy (SABR) is the standard treatment for
medically inoperable early-stage non-small-cell lung cancer (NSCLC), but regional or …
medically inoperable early-stage non-small-cell lung cancer (NSCLC), but regional or …
Microbial metabolite enhances immunotherapy efficacy by modulating T cell stemness in pan-cancer
The immune checkpoint blockade (ICB) response in human cancers is closely linked to the
gut microbiota. Here, we report that the abundance of commensal Lactobacillus johnsonii is …
gut microbiota. Here, we report that the abundance of commensal Lactobacillus johnsonii is …
Stem-like exhausted and memory CD8+ T cells in cancer
T cells can acquire a broad spectrum of differentiation states following activation. At the
extreme ends of this continuum are short-lived cells equipped with effector machinery and …
extreme ends of this continuum are short-lived cells equipped with effector machinery and …
[HTML][HTML] Principles and therapeutic applications of adaptive immunity
Adaptive immunity provides protection against infectious and malignant diseases. These
effects are mediated by lymphocytes that sense and respond with targeted precision to …
effects are mediated by lymphocytes that sense and respond with targeted precision to …
Localization, tissue biology and T cell state—implications for cancer immunotherapy
Tissue localization is a critical determinant of T cell immunity. CD8+ T cells are contact-
dependent killers, which requires them to physically be within the tissue of interest to kill …
dependent killers, which requires them to physically be within the tissue of interest to kill …
Lymph node metastasis in cancer progression: molecular mechanisms, clinical significance and therapeutic interventions
Lymph nodes (LNs) are important hubs for metastatic cell arrest and growth, immune
modulation, and secondary dissemination to distant sites through a series of mechanisms …
modulation, and secondary dissemination to distant sites through a series of mechanisms …
CD4+ T cell activation distinguishes response to anti-PD-L1+ anti-CTLA4 therapy from anti-PD-L1 monotherapy
Cancer patients often receive a combination of antibodies targeting programmed death-
ligand 1 (PD-L1) and cytotoxic T lymphocyte antigen-4 (CTLA4). We conducted a window-of …
ligand 1 (PD-L1) and cytotoxic T lymphocyte antigen-4 (CTLA4). We conducted a window-of …