Malaria, which is caused by infection of red blood cells with Plasmodium parasites, can be
fatal in non-immune individuals if left untreated. The recent approval of the pre-erythrocytic …

Infection by malaria parasites (Plasmodium spp.) remains one of the leading causes of
morbidity and mortality, especially in tropical regions of the world. Despite the availability of …

The Plasmodium falciparum proteasome constitutes a promising antimalarial target, with
multiple chemotypes potently and selectively inhibiting parasite proliferation and synergizing …

Measures to combat the parasites that cause malaria have become compromised because
of reliance on a small arsenal of drugs and emerging drug resistance. We conducted a …

Malaria still poses a major burden on human health around the world, especially in endemic
areas. Plasmodium resistance to several antimalarial drugs has been one of the major …

Malaria as vector-borne disease remains important health concern with over 200 million
cases globally. Novel antimalarial medicines and more effective vaccines must be …

Artemisinins (ART) are critical anti-malarials and despite their use in combination therapy,
ART-resistant Plasmodium falciparum is spreading globally. To counter ART resistance, we …

With over 200 million cases and close to half a million deaths each year, malaria is a threat
to global health, particularly in develo** countries. Plasmodium falciparum, the parasite …

Recent progress in genomics and molecular genetics has empowered novel approaches to
study gene functions in disease-causing pathogens. In the human malaria parasite …

Highlights•Many antimalarial drug targets discovered using reverse chemical genetic
methods are druggable in other species.•tRNA synthetases seem to be one of the most …