The past 25 years of genomics research first revealed which genes are encoded by the
human genome and then a detailed catalogue of human genome variation associated with …

Despite tremendous progress in the past decade, the complex and heterogeneous nature of
cancer complicates efforts to identify new therapies and therapeutic combinations that …

Alzheimer's disease is the leading cause of dementia worldwide, but the cellular pathways
that underlie its pathological progression across brain regions remain poorly understood …

The tricarboxylic acid (TCA) cycle is a central hub of cellular metabolism, oxidizing nutrients
to generate reducing equivalents for energy production and critical metabolites for …

To define the cellular composition and architecture of cutaneous squamous cell carcinoma
(cSCC), we combined single-cell RNA sequencing with spatial transcriptomics and …

Thousands of interactions assemble proteins into modules that impart spatial and functional
organization to the cellular proteome. Through affinity-purification mass spectrometry, we …

The human genome encodes approximately 20,000 proteins, many still uncharacterised. It
has become clear that scientific research tends to focus on well-studied proteins, leading to …

The selenoprotein glutathione peroxidase 4 (GPX4) prevents ferroptosis by converting lipid
peroxides into nontoxic lipid alcohols. GPX4 has emerged as a promising therapeutic target …

Cancer genomics studies have identified thousands of putative cancer driver genes.
Development of high-throughput and accurate models to define the functions of these genes …

Understanding the basis for cellular growth, proliferation, and function requires determining
the roles of essential genes in diverse cellular processes, including visualizing their …