Phagocytosis is a remarkably complex and versatile process: it contributes to innate
immunity through the ingestion and elimination of pathogens, while also being central to …

Chemokines play crucial roles in combating microbial infection and initiating tissue repair by
recruiting neutrophils in a timely and coordinated manner. In humans, no less than seven …

Phagocytosis is a specialized process that enables cellular ingestion and clearance of
microbes, dead cells and tissue debris that are too large for other endocytic routes. As such …

Integrins are cell adhesion molecules that mediate cell-cell, cell–extracellular matrix, and
cell-pathogen interactions. They play critical roles for the immune system in leukocyte …

Integrins are the principal cell adhesion receptors that mediate leukocyte migration and
activation in the immune system. These receptors signal bidirectionally through the plasma …

Rolling adhesion on vascular surfaces is the first step in recruiting circulating leukocytes,
hematopoietic progenitors, or platelets to specific organs or to sites of infection or injury …

For a cell to move forward it must convert chemical energy into mechanical propulsion.
Force produced by actin polymerization can generate traction across the plasma membrane …

Abbreviations used in this paper: APC, antigen-presenting cell; Bleb, blebbistatin; cSMAC,
central supramolecular activation cluster; dSMAC, distal SMAC; ICAM-1, intracellular cell …

T cell cytoarchitecture differs dramatically depending on whether the cell is circulating within
the bloodstream, migrating through tissues, or interacting with antigen-presenting cells. The …

Integrity of the dendritic cell (DC) actin cytoskeleton is essential for T cell priming, but the
underlying mechanisms are poorly understood. We show that the DC F-actin network …