Oxidative stress‐related mechanisms in schizophrenia pathogenesis and new treatment perspectives

EA Ermakov, EM Dmitrieva… - Oxidative Medicine …, 2021 - Wiley Online Library
Schizophrenia is recognized to be a highly heterogeneous disease at various levels, from
genetics to clinical manifestations and treatment sensitivity. This heterogeneity is also …

Clozapine's multiple cellular mechanisms: What do we know after more than fifty years? A systematic review and critical assessment of translational mechanisms …

A de Bartolomeis, L Vellucci, A Barone… - Pharmacology & …, 2022 - Elsevier
Almost fifty years after its first introduction into clinical care, clozapine remains the only
evidence-based pharmacological option for treatment-resistant schizophrenia (TRS), which …

[HTML][HTML] Endocrine disruption and obesity: A current review on environmental obesogens

R Gupta, P Kumar, N Fahmi, B Garg, S Dutta… - Current Research in …, 2020 - Elsevier
Obesity represents an important public health concern because it substantially increases the
risk of multiple chronic diseases and thereby contributing to a decline in both quality of life …

Evaluation of antioxidant enzymes activities and lipid peroxidation in schizophrenic patients treated with typical and atypical antipsychotics

M Padurariu, A Ciobica, I Dobrin, C Stefanescu - Neuroscience Letters, 2010 - Elsevier
Studies performed in schizophrenia patients have generally suggested the presence of a
compromised antioxidant system, but this is not always consistent with specific observed …

Atypical antipsychotics-induced metabolic syndrome and nonalcoholic fatty liver disease: a critical review

H Xu, X Zhuang - Neuropsychiatric disease and treatment, 2019 - Taylor & Francis
The atypical antipsychotics (AAPs) have been used as first-line drugs in psychiatric practice
for a wide range of psychotic disorders, including schizophrenia and bipolar mania. While …

Oxidation-reduction mechanisms in psychiatric disorders: A novel target for pharmacological intervention

AC Rossetti, MS Paladini, MA Riva, R Molteni - Pharmacology & …, 2020 - Elsevier
While neurotransmitter dysfunction represents a key component in mental illnesses, there is
now a wide agreement for a central pathophysiological hub that includes hormones …

Antipsychotics-induced metabolic alterations: focus on adipose tissue and molecular mechanisms

P Gonçalves, JR Araújo, F Martel - European Neuropsychopharmacology, 2015 - Elsevier
The use of antipsychotic drugs for the treatment of mood disorders and psychosis has
increased dramatically over the last decade. Despite its consumption being associated with …

Role of rutin nanoemulsion in ameliorating oxidative stress: pharmacokinetic and pharmacodynamics studies

S Sharma, SA Rabbani, JK Narang, FH Pottoo… - Chemistry and physics …, 2020 - Elsevier
Parkinson's disease is caused due to free radical generation in dopamine neurons leading
to oxidative stress induced damage. The aim of this work was to ameliorate the free radical …

Berberine ameliorate haloperidol and 3-Nitropropionic acid-induced neurotoxicity in rats

A Kadir, J Singh, V Rahi, P Kumar - Neurochemical Research, 2022 - Springer
Berberine due to its antioxidant properties, has been used around the globe significantly to
treat several brain disorders. Also, oxidative stress is a pathological hallmark in …

Clozapine-induced mitochondria alterations and inflammation in brain and insulin-responsive cells

V Contreras-Shannon, DL Heart, RM Paredes… - PloS one, 2013 - journals.plos.org
Background Metabolic syndrome (MetS) is a constellation of factors including abdominal
obesity, hyperglycemia, dyslipidemias, and hypertension that increase morbidity and …