In this review, we discuss the structural and functional diversity of protein–protein
interactions (PPIs) based primarily on protein families for which three‐dimensional structural …

The neuronal ceroid lipofuscinoses (NCLs) are clinically and genetically heterogeneous
neurodegenerative disorders. Most are autosomal recessively inherited. Clinical features …

Objective: Diverse autolysosomal proteins were quantified in neurally derived blood
exosomes from patients with Alzheimer disease (AD) and controls to investigate disordered …

Sequences flanking the AUG initiator codon influence its recognition by eukaryotic
ribosomes. From a comparison of several hundred mRNA sequences, CC AG CCAUGG …

Discovery of biosensors has acquired utmost importance in the field of healthcare. Recent
advances in biological techniques and instrumentation involving nanomaterials, surface …

ABSTRACT CTSD/CathD/CATD (cathepsin D) is a lysosomal aspartic protease. A
distinguishing characteristic of CTSD is its dual functions of promoting cell proliferation via …

Congenital neuronal ceroid-lipofuscinosis (NCL) is a devastating inherited
neurodegenerative disorder of unknown metabolic basis. Eight patients with this rare …

Angiotensin II regulates blood pressure and may affect adipogenesis and adipocyte
metabolism. Angiotensin II is produced by cleavage of angiotensinogen by renin and …

In Alzheimer's disease brains, more than 90% of pyramidal neurons in lamina V and 70% in
lamina III displayed 2-to 5-fold elevated levels of cathepsin D (Cat D) mRNA by in situ …

The fatal, primarily childhood neurodegenerative disorders, neuronal ceroid lipofuscinoses
(NCLs), are currently associated with mutations in 13 genes. The protein products of these …