Complement, a target for therapy in inflammatory and degenerative diseases
The complement system is a key innate immune defence against infection and an important
driver of inflammation; however, these very properties can also cause harm. Inappropriate or …
driver of inflammation; however, these very properties can also cause harm. Inappropriate or …
Cyclic peptides as drugs for intracellular targets: the next frontier in peptide therapeutic development
LK Buckton, MN Rahimi… - Chemistry–A European …, 2021 - Wiley Online Library
Develo** macrocyclic peptides that can reach intracellular targets is a significant
challenge. This review discusses the most recent strategies used to develop cell permeable …
challenge. This review discusses the most recent strategies used to develop cell permeable …
Harnessing protein folding neural networks for peptide–protein docking
Highly accurate protein structure predictions by deep neural networks such as AlphaFold2
and RoseTTAFold have tremendous impact on structural biology and beyond. Here, we …
and RoseTTAFold have tremendous impact on structural biology and beyond. Here, we …
Peptide therapeutics: targeting the undruggable space
N Tsomaia - European journal of medicinal chemistry, 2015 - Elsevier
Rapid advancements in genomics have brought a better understanding of molecular
mechanisms for various pathologies and identified a number of highly attractive target …
mechanisms for various pathologies and identified a number of highly attractive target …
A chemical perspective on the modulation of TEAD transcriptional activities: Recent progress, challenges, and opportunities
J Lou, Y Lu, J Cheng, F Zhou, Z Yan, D Zhang… - European Journal of …, 2022 - Elsevier
TEADs are transcription factors and core downstream components of the Hippo pathway.
Mutations of the Hippo pathway and/or dysregulation of YAP/TAZ culminate in aberrant …
Mutations of the Hippo pathway and/or dysregulation of YAP/TAZ culminate in aberrant …
Bent into shape: Folded peptides to mimic protein structure and modulate protein function
Protein secondary and tertiary structure mimics have served as model systems to probe
biophysical parameters that guide protein folding and as attractive reagents to modulate …
biophysical parameters that guide protein folding and as attractive reagents to modulate …
Peptiderive server: derive peptide inhibitors from protein–protein interactions
Y Sedan, O Marcu, S Lyskov… - Nucleic acids …, 2016 - academic.oup.com
Abstract The Rosetta Peptiderive protocol identifies, in a given structure of a protein–protein
interaction, the linear polypeptide segment suggested to contribute most to binding energy …
interaction, the linear polypeptide segment suggested to contribute most to binding energy …
Designing peptides on a quantum computer
Although a wide variety of quantum computers are currently being developed, actual
computational results have been largely restricted to contrived, artificial tasks. Finding ways …
computational results have been largely restricted to contrived, artificial tasks. Finding ways …
Elucidating the druggable interface of protein− protein interactions using fragment docking and coevolutionary analysis
Protein− protein interactions play a central role in cellular function. Improving the
understanding of complex formation has many practical applications, including the rational …
understanding of complex formation has many practical applications, including the rational …
Stabilized cyclic peptides as modulators of protein–protein interactions: Promising strategies and biological evaluation
J Cheng, J Zhou, L Kong, H Wang, Y Zhang… - RSC Medicinal …, 2023 - pubs.rsc.org
Protein–protein interactions (PPIs) control many essential biological pathways which are
often misregulated in disease. As such, selective PPI modulators are desirable to unravel …
often misregulated in disease. As such, selective PPI modulators are desirable to unravel …