Bony defects in the craniomaxillofacial skeleton remain a major and challenging health
concern. Surgeons have been trying for centuries to restore functionality and aesthetic …

One of the goals of bone tissue engineering is to design delivery methods for skeletal
stem/progenitor cells to repair or replace bone. Although the materials used to retain cells …

The maintenance of human skeletal stem cells (hSSCs) and their progeny in bone defects is
a major challenge. Here, we report on a transplantable bandage containing a three …

Regenerative medicine utilizes stem cells to repair damaged tissues by replacing them with
their differentiated cells and activating the body's inherent regenerative abilities …

Critical‐size osseous defects cannot heal without surgical intervention and can pose a
significant challenge to craniofacial reconstruction. Autologous bone grafting is the gold …

The treatment of long bone defects and non-unions is still a major clinical and socio-
economical problem. In addition to the non-operative therapeutic options, such as the …

In modern science, immortalized cells are not only a convenient tool in fundamental
research, but they are also increasingly used in practical medicine. This happens due to …

The Hedgehog pathway functions as an organizer in embryonic development. Aberrant
activation of the Hedgehog pathway has been reported in various types of malignant …

Background Human mesenchymal stem cells (MSC) are important tools for several cell-
based therapies. However, their use in such therapies requires in vitro expansion during …

Neben stabilisierenden Osteosynthesetechniken und der autologen Knochentransplantation
spielen Orthobiologika bei der Behandlung von Knochenheilungsstörungen eine …