Atherosclerosis is a chronic inflammatory disease of the arterial wall and the primary
underlying cause of cardiovascular disease. Data from in vivo imaging, cell-lineage tracing …

Inflammation is essential in the initial development and progression of many cardiovascular
diseases involving innate and adaptive immune responses. The role of CD4+ CD25+ …

Acute cardiomyocyte necrosis in the infarcted heart generates damage-associated
molecular patterns, activating complement and toll-like receptor/interleukin-1 signaling, and …

Cardiovascular disease is the leading cause of mortality worldwide, and atherosclerosis the
principal factor underlying cardiovascular events. Atherosclerosis is a chronic inflammatory …

During infections or acute conditions high-density lipoproteins cholesterol (HDL-C) levels
decrease very rapidly and HDL particles undergo profound changes in their composition …

Both the chronic development of atherosclerotic lesions and the acute changes in lesion
phenotype that lead to clinical cardiovascular events are significantly influenced by the …

Regulatory T cells (Tregs) play an important role in the regulation of T-cell–mediated
immune responses through suppression of T-cell proliferation and secretion of inhibitory …

Cholesterol homeostasis has a pivotal function in regulating immune cells. Here we show
that apolipoprotein E (apoE) deficiency leads to the accumulation of cholesterol in the cell …

The immune response requires major changes to metabolic processes, and indeed, energy
metabolism and functional activation are fully integrated in immune cells to determine their …

Low-grade systemic inflammation associated to obesity leads to cardiovascular
complications, caused partly by infiltration of adipose and vascular tissue by effector T cells …