Fibroblasts are typical mesenchymal cells widely distributed throughout the human body
where they (1) synthesise and maintain the extracellular matrix, ensuring the structural role …

Skin photoaging, resulting from prolonged exposure to ultraviolet radiation, is a form of
exogenous aging that not only impacts the aesthetic aspect of the skin but also exhibits a …

The lifespan extension induced by 40% caloric restriction (CR) in rodents is accompanied by
postponement of disease, preservation of function, and increased stress resistance. Whether …

N6-methyladenosine (m6A), the most prevalent posttranscriptional RNA modification,
involved in various diseases and cellular processes. However, the underlying mechanisms …

Abstract Changes in the transcriptomes of human tissues with advancing age are poorly
cataloged. Here, we sought to identify the coding and long noncoding RNAs present in …

Since ancient times aging has also been regarded as a disease, and humankind has always
strived to extend the natural lifespan. Analyzing the genes involved in aging and disease …

Background Skin aging is the most obvious feature of human aging, and delaying aging has
become a hot and difficult research topic in aesthetic medicine. The accumulation of …

Cellular senescence increases with age and contributes to age-related declines and
pathologies. We identified circulating biomarkers of senescence associated with diverse …

Abstract Background Human dermal fibroblasts (HDFs) are essential in the processes of
skin ageing and wound healing. However, the underlying mechanism of HDFs in skin …

DNA methylation is an important epigenetic mechanism that helps define and maintain
cellular functions. It is influenced by many factors, including environmental exposures …