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The origin of the genetic code: amino acids as cofactors in an RNA world
E Szathmáry - Trends in Genetics, 1999 - cell.com
The genetic code, understood as the specific assignment of amino acids to nucleotide
triplets, might have preceded the existence of translation. Amino acids became utilized as …
triplets, might have preceded the existence of translation. Amino acids became utilized as …
Coevolution theory of the genetic code at age thirty
JTF Wong - BioEssays, 2005 - Wiley Online Library
The coevolution theory of the genetic code, which postulates that prebiotic synthesis was an
inadequate source of all twenty protein amino acids, and therefore some of them had to be …
inadequate source of all twenty protein amino acids, and therefore some of them had to be …
Consensus temporal order of amino acids and evolution of the triplet code
EN Trifonov - Gene, 2000 - Elsevier
Forty different single-factor criteria and multi-factor hypotheses about chronological order of
appearance of amino acids in the early evolution are summarized in consensus ranking. All …
appearance of amino acids in the early evolution are summarized in consensus ranking. All …
The triplet code from first principles
EN Trifonov - Journal of Biomolecular structure and dynamics, 2004 - Taylor & Francis
Abstract Temporal order (“chronology”) of appearance of amino acids and their respective
codons on evolutionary scene is reconstructed. A consensus chronology of amino acids is …
codons on evolutionary scene is reconstructed. A consensus chronology of amino acids is …
An extension of the coevolution theory of the origin of the genetic code
Background The coevolution theory of the origin of the genetic code suggests that the
genetic code is an imprint of the biosynthetic relationships between amino acids. However …
genetic code is an imprint of the biosynthetic relationships between amino acids. However …
The origin of the genetic code: theories and their relationships, a review
A review of the main theories proposed to explain the origin of the genetic code is
presented. I analyze arguments and data in favour of different theories proposed to explain …
presented. I analyze arguments and data in favour of different theories proposed to explain …
Theories of the origin of the genetic code: Strong corroboration for the coevolution theory
I analyzed all the theories and models of the origin of the genetic code, and over the years, I
have considered the main suggestions that could explain this origin. The conclusion of this …
have considered the main suggestions that could explain this origin. The conclusion of this …
Transfer RNA paralogs: evidence for genetic code-amino acid biosynthesis coevolution and an archaeal root of life
A search has been performed on 2878 tRNA sequences from 60 different genomes in order
to detect the existence of closely related 'alloacceptor'tRNAs accepting dissimilar amino …
to detect the existence of closely related 'alloacceptor'tRNAs accepting dissimilar amino …
Spontaneous evolution of circular codes in theoretical minimal RNA rings
Small circular RNAs occur in many cells. Theoretical considerations designed to mimick
primordial RNAs designed 25 theoretical, minimal 22-nucleotide long circular RNAs (RNA …
primordial RNAs designed 25 theoretical, minimal 22-nucleotide long circular RNAs (RNA …
Testing a biosynthetic theory of the genetic code: fact or artifact?
It has long been conjectured that the canonical genetic code evolved from a simpler
primordial form that encoded fewer amino acids [eg, Crick, FHC (1968) J. Mol. Biol. 38, 367 …
primordial form that encoded fewer amino acids [eg, Crick, FHC (1968) J. Mol. Biol. 38, 367 …