The metastatic niche and stromal progression
JP Sleeman - Cancer and Metastasis Reviews, 2012 - Springer
The tumor stroma is comprised of extracellular matrix, non-malignant cells, and the signaling
molecules they produce. It is an integral and vital component of primary tumors that together …
molecules they produce. It is an integral and vital component of primary tumors that together …
Chimeric antigen receptor (CAR) T cell therapy for metastatic melanoma: challenges and road ahead
Metastatic melanoma is the most aggressive and difficult to treat type of skin cancer, with a
survival rate of less than 10%. Metastatic melanoma has conventionally been considered …
survival rate of less than 10%. Metastatic melanoma has conventionally been considered …
Brachytherapy via a depot of biopolymer-bound 131I synergizes with nanoparticle paclitaxel in therapy-resistant pancreatic tumours
Locally advanced pancreatic tumours are highly resistant to conventional
radiochemotherapy. Here we show that such resistance can be surmounted by an injectable …
radiochemotherapy. Here we show that such resistance can be surmounted by an injectable …
Engineering of cell microenvironment-responsive polypeptide nanovehicle co-encapsulating a synergistic combination of small molecules for effective chemotherapy …
In this study, we report a facile method to construct a bioactive (poly (phenylalanine)-b-poly
(l-histidine)-b-poly (ethylene glycol) polypeptide nanoconstruct to co-load doxorubicin (DOX) …
(l-histidine)-b-poly (ethylene glycol) polypeptide nanoconstruct to co-load doxorubicin (DOX) …
Multimodal selenium nanoshell-capped Au@mSiO2 nanoplatform for NIR-responsive chemo-photothermal therapy against metastatic breast cancer
Multimodal therapeutic agents based on novel nanomaterials for multidrug resistance have
attracted increasing attention in cancer therapy. In this study, we describe the construction of …
attracted increasing attention in cancer therapy. In this study, we describe the construction of …
Lung‐endothelium‐targeted nanoparticles based on a pH‐sensitive lipid and the GALA peptide enable robust gene silencing and the regression of metastatic lung …
The development of efficient gene delivery systems targeting the lung endothelium remains
a serious challenge. This study reports on the design and optimization of a multifunctional …
a serious challenge. This study reports on the design and optimization of a multifunctional …
Delivery of therapeutic siRNA to the lung endothelium via novel lipoplex formulation DACC
Posttranscriptional gene silencing by RNA interference can be therapeutically exploited to
inhibit pathophysiological gene expression. However, in contrast to the established …
inhibit pathophysiological gene expression. However, in contrast to the established …
PECAM-1 isoforms, eNOS and endoglin axis in regulation of angiogenesis
S Park, CM Sorenson, N Sheibani - Clinical science, 2015 - portlandpress.com
Vascular development and maintenance of proper vascular function through various
regulatory mechanisms are critical to our wellbeing. Delineation of the regulatory processes …
regulatory mechanisms are critical to our wellbeing. Delineation of the regulatory processes …
Lipid envelope-type nanoparticle incorporating a multifunctional peptide for systemic siRNA delivery to the pulmonary endothelium
A system that permits the delivery of cargoes to the lung endothelium would be
extraordinarily useful in terms of curing a wide variety of lung-related diseases. This study …
extraordinarily useful in terms of curing a wide variety of lung-related diseases. This study …
Facile construction of bioreducible crosslinked polypeptide micelles for enhanced cancer combination therapy
In this study, we developed pH and redox-responsive crosslinked polypeptide-based
combination micelles for enhanced chemotherapeutic efficacy and minimized side effects …
combination micelles for enhanced chemotherapeutic efficacy and minimized side effects …