Tissue repair is critical for animal survival. The skin epidermis is particularly exposed to
injuries, which necessitates rapid repair. The coordinated action of distinct epidermal stem …

Tissues have a natural capacity to replace dying cells and to heal wounds. This ability
resides in resident stem cells, which self-renew, preserve, and repair their tissue during …

The vast blood-vessel network of the circulatory system is crucial for maintaining bodily
homeostasis, delivering essential molecules and blood cells, and removing waste products …

Skin architecture and function depend on diverse populations of epidermal cells and dermal
fibroblasts. Reciprocal communication between the epidermis and dermis plays a key role in …

Maintenance of adult tissues depends on sustained activity of resident stem cell populations,
but the mechanisms that regulate stem cell self-renewal during homeostasis remain largely …

All adult tissues experience wear and tear. Most tissues can compensate for cell loss
through the activity of resident stem cells. Although the cellular maintenance strategies vary …

Mammalian skin and its appendages constitute the integumentary system forming a barrier
between the organism and its environment. During development, skin epidermal cells divide …

Type XVII collagen (COL17) is a transmembrane protein located at the epidermal basement
membrane zone. COL17 deficiency results in premature hair aging phenotypes and in …

Stem cells are the essential source of building blocks for tissue homeostasis and
regeneration. Their behavior is dictated by both cell‐intrinsic cues and extrinsic cues from …

Skin is the largest organ of the human body. Its architecture and physiological functions
depend on diverse populations of epidermal cells and dermal fibroblasts. Reciprocal …