Vascular cognitive impairment (VCI) is a lifelong process encompassing a broad spectrum of
cognitive disorders, ranging from subtle or mild deficits to prodromal and fully developed …

Amyotrophic lateral sclerosis (ALS) is the most common form of human motor neuron
disease. It is characterized by the progressive degeneration of upper and lower motor …

Studies have shown that women on the Alzheimer's disease (AD) continuum have more
pathological tau in the brain and cerebrospinal fluid (CSF), than men. Some studies have …

Background Efforts to enhance diagnostic measures for sarcopenia have led to an
increased focus on the screening utility of blood‐based biomarkers. In this regard …

Multiple sclerosis (MS) is a chronic demyelinating and neuroinflammatory disease of the
human central nervous system with complex pathoetiology, heterogeneous presentations …

Established by brain endothelial cells, the blood–brain barrier (BBB) regulates the trafficking
of molecules, restricts immune cell entry into the CNS, and has an active role in …

INTRODUCTION Amyloid‐β (Aβ) and tau can be quantified in blood. However, biological
factors can influence the levels of brain‐derived proteins in the blood. The blood‐brain …

Traumatic brain injury (TBI) affects millions of Americans each year and has been shown to
disproportionately impact those subject to greater disparities in health. Female sex is one …

The definition of Alzheimer's disease (AD) now considers the presence of the markers of
amyloid (A), tau deposition (T), and neurodegeneration (N) essential for diagnosis. AD …

Abstract Objectives Neurofilament light chain (NfL) is an emerging biomarker of
neurodegeneration disorders. Knowledge of the biological variation (BV) can facilitate …