Moving from poly (ADP-ribose) polymerase inhibition to targeting DNA repair and DNA damage response in cancer therapy
The DNA damage response (DDR) pathway coordinates the identification, signaling, and
repair of DNA damage caused by endogenous or exogenous factors and regulates cell …
repair of DNA damage caused by endogenous or exogenous factors and regulates cell …
Major molecular signaling pathways in oral cancer associated with therapeutic resistance
Oral cancer is a sub-category of head and neck cancers that primarily initiates in the oral
cavity. The primary treatment option for oral cancer remains surgery but it is associated with …
cavity. The primary treatment option for oral cancer remains surgery but it is associated with …
ITCH as a potential therapeutic target in human cancers
Abstract The ITCH/AIP4 ubiquitin E3 ligase was discovered independently by two groups
searching for atrophin-1 interacting proteins and studying the genetics of mouse coat color …
searching for atrophin-1 interacting proteins and studying the genetics of mouse coat color …
PARP inhibitors in prostate cancer
Opinion Statement The genomic landscape of metastatic prostate cancer (mPCa) reveals
that up to 90% of patients harbor actionable mutations and> 20% have somatic DNA repair …
that up to 90% of patients harbor actionable mutations and> 20% have somatic DNA repair …
Preoperative ctDNA levels are associated with poor overall survival in patients with ovarian cancer
A Dobilas, Y Chen, C Brueffer… - Cancer Genomics & …, 2023 - cgp.iiarjournals.org
Abstract Background/Aim: Circulating tumor DNA (ctDNA), which is shed from cancer cells
into the bloodstream, offers a potential minimally invasive approach for cancer diagnosis …
into the bloodstream, offers a potential minimally invasive approach for cancer diagnosis …
Genomic changes driven by radiation-induced DNA damage and microgravity in human cells
The space environment consists of a complex mixture of different types of ionizing radiation
and altered gravity that represents a threat to humans during space missions. In particular …
and altered gravity that represents a threat to humans during space missions. In particular …
Sequential targeting of PARP with carboplatin inhibits primary tumour growth and distant metastasis in triple-negative breast cancer
M Beniey, A Hubert, T Haque, AK Cotte… - British Journal of …, 2023 - nature.com
Background Patients with triple-negative breast cancer (TNBC) develop early recurrence.
While PARP inhibitors (PARPi) have demonstrated potential in BRCA1/2-mutant …
While PARP inhibitors (PARPi) have demonstrated potential in BRCA1/2-mutant …
[HTML][HTML] Excess growth hormone suppresses DNA damage repair in epithelial cells
V Chesnokova, S Zonis, R Barrett, H Kameda… - JCI insight, 2019 - ncbi.nlm.nih.gov
Growth hormone (GH) decreases with age, and GH therapy has been advocated by some to
sustain lean muscle mass and vigor in aging patients and advocated by athletes to enhance …
sustain lean muscle mass and vigor in aging patients and advocated by athletes to enhance …
Multi-label deep learning for gene function annotation in cancer pathways
The war on cancer is progressing globally but slowly as researchers around the world
continue to seek and discover more innovative and effective ways of curing this catastrophic …
continue to seek and discover more innovative and effective ways of curing this catastrophic …
DNA damage repair deficiency in prostate cancer
Molecular-targeted therapies and treatment stratification based on molecular biomarkers
have rapidly gained momentum in the therapeutic spectrum for patients with prostate cancer …
have rapidly gained momentum in the therapeutic spectrum for patients with prostate cancer …