Exosomes are small extracellular vesicles that are secreted by almost all types of cells and
exist in almost all extracellular spaces. As an important mediator of intercellular …

Cancer as we know it is actually an umbrella term for over 100 very unique malignancies in
various tissues throughout the human body. Each type, and even subtype of cancer, has …

Hypoxia is a key feature of solid tumors, associated with disease aggressiveness and poor
outcome. Besides undergoing broad intracellular molecular and metabolic adaptations …

Prostate cancer (PCa) metastasizes selectively to bone through unknown mechanisms. In
the current study, we identified exosome-mediated transfer of pyruvate kinase M2 (PKM2) …

Sensitive early detection, along with effective treatments and solid postoperative monitoring
remain the grand challenges in fighting against human diseases, especially cancer.(1) In …

Exosomes are membrane-enclosed nanovesicles that shuttle active cargoes, such as
mRNAs and microRNAs (miRNAs), between different cells. Mesenchymal stem cells (MSCs) …

Predicting the risk of metastasis before starting prostate cancer (PCa) treatment can
minimize the overtreatment of indolent cases and help choosing appropriate treatment. The …

The term extracellular vesicles (EVs) refers to a variety of heterogeneous nanovesicles
secreted by almost all cell types, primarily for intercellular communication and maintaining …

MicroRNAs (miRNAs) are endogenous, non-coding, single-stranded small RNAs involved in
a variety of cellular processes, including ontogeny, cell proliferation, differentiation, and …

Exosomes are structurally and functionally pleiotropic nano-sized (~ 30–150 nm in diameter)
extracellular vesicles (EVs) with endosomal origin. These vesicles are secreted by almost all …