In this review we summarize the current understanding of signal transduction downstream of
vascular endothelial growth factor A (VEGFA) and its receptor VEGFR 2, and the relationship …

Vascular endothelial growth factor A (VEGF-A) is upregulated during hypoxia and is the
major regulator of angiogenesis. VEGF-A expression has also been found to recruit myeloid …

The pathogenesis of inflammatory bowel diseases (IBD), such as ulcerative colitis (UC) and
Crohn's disease (CD) is complex, and our knowledge on the topic is constantly growing. The …

Cerebral cavernous malformations (CCMs) are dilated capillaries causing epilepsy and
stroke. Inheritance of a heterozygous mutation in CCM3/PDCD10 is responsible for the most …

Accumulating evidence indicated that circular RNAs (circRNAs) are crucial regulators in
tumorigenesis of hepatocellular carcinoma (HCC), but it is still unclear how …

Primary multiple intracranial aneurysm (MIA) is a vascular disease that frequently leads to
fatal vascular rupture and subarachnoid hemorrhage. However, the epigenetic regulation …

Background. Cycloastragenol (CAG) has been reported to alleviate airway inflammation in
ovalbumin‐(OVA‐) induced asthmatic mice. However, its specific mechanisms remain …

Abstract IL-2/IL-2R inhibition improved the prognosis of ischemic stroke by regulating T cells,
while the respective contribution of T cells with high/medium/low-affinity IL-2 receptors …

Background: Crohn's disease (CD) may progress from an inflammatory to a stricturing or
penetrating disease phenotype. The aim of our study was to identify single nucleotide …

Background Familial hypercholesterolemia (FH) is one of the commonest inherited
metabolic disorders. Abnormally high level of low-density lipoprotein cholesterol (LDL-C) in …