Tryptase is a protein expressed by mast cells and basophils. 1, 2 Mature, enzymatically
active tryptases are tetrameric serine proteases that are stored in mast cell secretory …

Physiologic levels of basal serum tryptase vary among healthy individuals, depending on
the numbers of mast cells, basal secretion rate, copy numbers of the TPSAB1 gene …

Mast cells (MC s) are derived from committed precursors that leave the hematopoietic tissue,
migrate in the blood, and colonize peripheral tissues where they terminally differentiate …

The most abundant prestored enzyme of human mast cell secretory granules is the serine-
protease tryptase. In humans, there are four tryptase isoforms, but only two of them, namely …

Hereditary alpha-tryptasemia (HαT) is an autosomal dominant genetic trait found in 4% to
6% of the general population and defined by excess copies of alpha-tryptase at TPSAB1 …

Background Hereditary-alpha tryptasemia (HαT) is the most common etiology for elevated
basal serum tryptase (BST). However, the utility of tryptase genoty** of individuals with …

Mastocytosis is a clonal disorder characterized by the proliferation and accumulation of mast
cells (MC) in different tissues, with a preferential localization in skin and bone marrow (BM) …

Objective To aid the clinician in correctly interpreting serum tryptase levels. Data Sources
Primary peer-reviewed literature. Study Selections Clinical and basic science peer-reviewed …

One of the most important blood tests in the field of allergy, mast cell tryptase has numerous
diagnostic uses, particularly for anaphylactic reactions and for the diagnosis of mastocytosis …

During the past few years, a number of molecular markers have been developed in clinical
hematology, most of them related to specific gene defects. However, there is also an unmet …