Oxidative stress in intervertebral disc degeneration: molecular mechanisms, pathogenesis and treatment

Y Wang, H Cheng, T Wang, K Zhang, Y Zhang… - Cell …, 2023‏ - Wiley Online Library
Low back pain (LBP) is a leading cause of labour loss and disability worldwide, and it also
imposes a severe economic burden on patients and society. Among symptomatic LBP …

Skeletal muscle oxidative stress and inflammation in aging: Focus on antioxidant and anti-inflammatory therapy

M Chen, Y Wang, S Deng, Z Lian, K Yu - Frontiers in Cell and …, 2022‏ - frontiersin.org
With aging, the progressive loss of skeletal muscle will have negative effect on multiple
physiological parameters, such as exercise, respiration, thermoregulation, and metabolic …

[HTML][HTML] Carnosine, small but mighty—prospect of use as functional ingredient for functional food formulation

I Jukić, N Kolobarić, A Stupin, A Matić, N Kozina… - Antioxidants, 2021‏ - mdpi.com
Carnosine is a dipeptide synthesized in the body from β-alanine and L-histidine. It is found
in high concentrations in the brain, muscle, and gastrointestinal tissues of humans and is …

[HTML][HTML] Research advances on the damage mechanism of skin glycation and related inhibitors

W Zheng, H Li, Y Go, XH Chan, Q Huang, J Wu - Nutrients, 2022‏ - mdpi.com
Our skin is an organ with the largest contact area between the human body and the external
environment. Skin aging is affected directly by both endogenous factors and exogenous …

[HTML][HTML] Antioxidant and neuroprotective effects of carnosine: therapeutic implications in neurodegenerative diseases

C Solana-Manrique, FJ Sanz, G Martínez-Carrión… - Antioxidants, 2022‏ - mdpi.com
Neurodegenerative diseases (NDs) constitute a global challenge to human health and an
important social and economic burden worldwide, mainly due to their growing prevalence in …

Understanding the antioxidant and carbonyl sequestering activity of carnosine: direct and indirect mechanisms

G Aldini, B de Courten, L Regazzoni… - Free radical …, 2021‏ - Taylor & Francis
Carnosine is an endogenous dipeptide whose oral administration has been found to prevent
several oxidative based diseases including lung disease, type 2 diabetes and its micro and …

Salidroside protects against osteoporosis in ovariectomized rats by inhibiting oxidative stress and promoting osteogenesis via Nrf2 activation

YF Wang, Y Chang, X Zhang, MT Gao, Q Zhang, X Li… - Phytomedicine, 2022‏ - Elsevier
Background Osteoporosis (OP) is characterized as low bone mass, bone microarchitecture
breakdown and bone fragility. The increase of oxidative stress could lead to breakdown in …

Anti-inflammatory and antioxidant traditional Chinese Medicine in treatment and prevention of osteoporosis

Q Li, C Tian, X Liu, D Li, H Liu - Frontiers in Pharmacology, 2023‏ - frontiersin.org
A metabolic bone disorder called osteoporosis is characterized by decreased bone mass
and compromised microarchitecture. This condition can deteriorate bones and raise the risk …

[HTML][HTML] The therapeutic potential of carnosine: Focus on cellular and molecular mechanisms

G Caruso, L Di Pietro, V Cardaci, S Maugeri… - Current Research in …, 2023‏ - Elsevier
Carnosine is a naturally occurring endogenous dipeptide composed by the ligation of β-
alanine and L-histidine performed particularly by tissues with an increased oxidative …

Therapeutic potential of carnosine and its derivatives in the treatment of human diseases

K Chmielewska, K Dzierzbicka… - Chemical Research …, 2020‏ - ACS Publications
Despite significant progress in the pathogenesis, diagnosis, treatment, and prevention of
cancer and neurodegenerative diseases, their occurrence and mortality are still high around …