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Current state and future directions in the therapy of ALS
L Tzeplaeff, S Wilfling, MV Requardt, M Herdick - Cells, 2023 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder
affecting upper and lower motor neurons, with death resulting mainly from respiratory failure …
affecting upper and lower motor neurons, with death resulting mainly from respiratory failure …
Physical principles of brain–computer interfaces and their applications for rehabilitation, robotics and control of human brain states
AE Hramov, VA Maksimenko, AN Pisarchik - Physics Reports, 2021 - Elsevier
Brain–computer interfaces (BCIs) development is closely related to physics. In this paper, we
review the physical principles of BCIs, and underlying novel approaches for registration …
review the physical principles of BCIs, and underlying novel approaches for registration …
A high-performance neuroprosthesis for speech decoding and avatar control
SL Metzger, KT Littlejohn, AB Silva, DA Moses… - Nature, 2023 - nature.com
Speech neuroprostheses have the potential to restore communication to people living with
paralysis, but naturalistic speed and expressivity are elusive. Here we use high-density …
paralysis, but naturalistic speed and expressivity are elusive. Here we use high-density …
[HTML][HTML] Walking naturally after spinal cord injury using a brain–spine interface
H Lorach, A Galvez, V Spagnolo, F Martel, S Karakas… - Nature, 2023 - nature.com
A spinal cord injury interrupts the communication between the brain and the region of the
spinal cord that produces walking, leading to paralysis 1, 2. Here, we restored this …
spinal cord that produces walking, leading to paralysis 1, 2. Here, we restored this …
Neuroprosthesis for decoding speech in a paralyzed person with anarthria
DA Moses, SL Metzger, JR Liu… - … England Journal of …, 2021 - Mass Medical Soc
Background Technology to restore the ability to communicate in paralyzed persons who
cannot speak has the potential to improve autonomy and quality of life. An approach that …
cannot speak has the potential to improve autonomy and quality of life. An approach that …
Generalizable spelling using a speech neuroprosthesis in an individual with severe limb and vocal paralysis
SL Metzger, JR Liu, DA Moses, ME Dougherty… - Nature …, 2022 - nature.com
Neuroprostheses have the potential to restore communication to people who cannot speak
or type due to paralysis. However, it is unclear if silent attempts to speak can be used to …
or type due to paralysis. However, it is unclear if silent attempts to speak can be used to …
High-performance brain-to-text communication via handwriting
FR Willett, DT Avansino, LR Hochberg, JM Henderson… - Nature, 2021 - nature.com
Brain–computer interfaces (BCIs) can restore communication to people who have lost the
ability to move or speak. So far, a major focus of BCI research has been on restoring gross …
ability to move or speak. So far, a major focus of BCI research has been on restoring gross …
Long-term wireless streaming of neural recordings for circuit discovery and adaptive stimulation in individuals with Parkinson's disease
Neural recordings using invasive devices in humans can elucidate the circuits underlying
brain disorders, but have so far been limited to short recordings from externalized brain …
brain disorders, but have so far been limited to short recordings from externalized brain …
Translational opportunities and challenges of invasive electrodes for neural interfaces
Invasive brain–machine interfaces can restore motor, sensory and cognitive functions.
However, their clinical adoption has been hindered by the surgical risk of implantation and …
However, their clinical adoption has been hindered by the surgical risk of implantation and …
Spelling interface using intracortical signals in a completely locked-in patient enabled via auditory neurofeedback training
U Chaudhary, I Vlachos, JB Zimmermann… - Nature …, 2022 - nature.com
Patients with amyotrophic lateral sclerosis (ALS) can lose all muscle-based routes of
communication as motor neuron degeneration progresses, and ultimately, they may be left …
communication as motor neuron degeneration progresses, and ultimately, they may be left …