Noncanonical NF-κB signaling differs from canonical NF-κB signaling by being activated
through different cell surface receptors, cytoplasmic adaptors, and NF-κB dimers. Under …

The realization that alterations in inhibitor of apoptosis (IAP) proteins are found in many
types of human cancer and are associated with chemoresistance, disease progression and …

The inflammatory response of mammalian cells to TNF-α can be switched to apoptosis either
by cotreatment with a protein synthesis inhibitor, cycloheximide, or Smac mimetic, a small …

Nuclear factor κB (NF-κB) transcription factors have a key role in many physiological
processes such as innate and adaptive immune responses, cell proliferation, cell death, and …

The receptor-interacting protein kinase 3 (RIP3/RIPK3) has emerged as a critical regulator of
programmed necrosis/necroptosis, an inflammatory form of cell death with important …

XIAP prevents apoptosis by binding to and inhibiting caspases, and this inhibition can be
relieved by IAP antagonists, such as Smac/DIABLO. IAP antagonist compounds (IACs) have …

The heterogeneity and instability of human tumors hamper straightforward identification of
cancer-causing mutations through genomic approaches alone. Herein we describe a mouse …

The proper regulation of apoptosis is essential for the survival of multicellular organisms.
Furthermore, excessive apoptosis can contribute to neurodegenerative diseases, anaemia …

Induction of selective degradation of target proteins by small molecules (protein knockdown)
would be useful for biological research and treatment of various diseases. To achieve …

Recent studies suggest that nuclear factor κB-inducing kinase (NIK) is suppressed through
constitutive proteasome-mediated degradation regulated by TRAF2, TRAF3 and cIAP1 or …