The determination of the crystal structures of small-molecule transporters has shed light on
the conformational changes that take place during structural isomerization from outward-to …

There are two classes of glucose transporters involved in glucose homeostasis in the body,
the facilitated transporters or uniporters (GLUTs) and the active transporters or symporters …

Abstract Na+/Cl–-coupled biogenic amine transporters are the primary targets of therapeutic
and abused drugs, ranging from antidepressants to the psychostimulants cocaine and …

Since determination of the myoglobin structure in 1957, X-ray crystallography, as the
anchoring tool of structural biology, has played an instrumental role in deciphering the …

The neurotransmitter transporters (NTTs) belonging to the solute carrier 6 (SLC6) gene
family (also referred to as the neurotransmitter-sodium-symporter family or Na+/Cl …

Active iodide (I−) transport in both the thyroid and some extrathyroidal tissues is mediated by
the Na+/I− symporter (NIS). In the thyroid, NIS-mediated I− uptake plays a pivotal role in …

Extensively revised, the fourth edition of this highly successful book takes into account the
many newly determined protein structures that provide molecular insight into chemiosmotic …

Abstract The Na+/I− symporter (NIS) is the plasma membrane glycoprotein that mediates
active I− transport in the thyroid and other tissues, such as salivary glands, stomach …

Neurotransmitter sodium symporters are integral membrane proteins that remove chemical
transmitters from the synapse and terminate neurotransmission mediated by serotonin …

After decades of slow progress, the pace of research on membrane protein structures is
beginning to quicken thanks to various improvements in technology, including protein …