The adult skeleton regenerates by temporary cellular structures that comprise teams of
juxtaposed osteoclasts and osteoblasts and replace periodically old bone with new. A …

Acidic extracellular pH is a major feature of tumor tissue, extracellular acidification being
primarily considered to be due to lactate secretion from anaerobic glycolysis …

CLC anion transporters are found in all phyla and form a gene family of eight members in
mammals. Two CLC proteins, each of which completely contains an ion translocation …

Cells in osteoclast and osteoblast lineages communicate with each other through cell–cell
contact, diffusible paracrine factors and cell–bone matrix interaction. Osteoclast–osteoblast …

OBJECTIVES: To review the current literature on the regulation of bone remodelling at the
cellular level. DESIGN AND METHODS: The cellular activities of the cells in the basic …

Bone remodeling is essential for the repair and replacement of damaged and old bone. The
major principle underlying this process is that osteoclast-mediated resorption of a quantum …

Monocytes and macrophages are innate immune cells with diverse functions ranging from
phagocytosis of microorganisms to forming a bridge with the adaptive immune system. A …

Bone remodeling is required for healthy calcium homeostasis and for repair of damage
occurring with stress and age. Osteoclasts resorb bone and osteoblasts form bone. These …

ABSTRACT CLC genes are expressed in species from bacteria to human and encode Cl−-
channels or Cl−/H+-exchangers. CLC proteins assemble to dimers, with each monomer …

BACKGROUND & AIMS: Drugs that inhibit gastric acid might increase the risk of hip fracture.
However, little long-term exposure data exist and no large studies have been conducted in …