Physics of cell adhesion: some lessons from cell-mimetic systems
E Sackmann, AS Smith - Soft matter, 2014 - pubs.rsc.org
Cell adhesion is a paradigm of the ubiquitous interplay of cell signalling, modulation of
material properties and biological functions of cells. It is controlled by competition of short …
material properties and biological functions of cells. It is controlled by competition of short …
Recent advances and prospects in the research of nascent adhesions
B Henning Stumpf, A Ambriović-Ristov… - Frontiers in …, 2020 - frontiersin.org
Nascent adhesions are submicron transient structures promoting the early adhesion of cells
to the extracellular matrix. Nascent adhesions typically consist of several tens of integrins …
to the extracellular matrix. Nascent adhesions typically consist of several tens of integrins …
Measuring shape fluctuations in biological membranes
C Monzel, K Sengupta - Journal of Physics D: Applied Physics, 2016 - iopscience.iop.org
Shape fluctuations of lipid membranes have intrigued cell biologists and physicists alike. In
the cellular context, their origin—thermal or active—and their physiological significance are …
the cellular context, their origin—thermal or active—and their physiological significance are …
Membrane fluctuations mediate lateral interaction between cadherin bonds
The integrity of living tissues is maintained by adhesion domains of trans-bonds formed
between cadherin proteins residing on opposing membranes of neighbouring cells. These …
between cadherin proteins residing on opposing membranes of neighbouring cells. These …
Membrane fluctuation model for understanding the effect of receptor nanoclustering on the activation of natural killer cells through biomechanical feedback
We investigated the role of ligand clustering and density in the activation of natural killer
(NK) cells. To that end, we designed reductionist arrays of nanopatterned ligands arranged …
(NK) cells. To that end, we designed reductionist arrays of nanopatterned ligands arranged …
The formation of ordered nanoclusters controls cadherin anchoring to actin and cell–cell contact fluidity
Oligomerization of cadherins could provide the stability to ensure tissue cohesion.
Cadherins mediate cell–cell adhesion by forming trans-interactions. They form cis …
Cadherins mediate cell–cell adhesion by forming trans-interactions. They form cis …
Criticality in cell adhesion
We illuminate the many-body effects underlying the structure, formation, and dissolution of
cellular adhesion domains in the presence and absence of forces. We consider mixed …
cellular adhesion domains in the presence and absence of forces. We consider mixed …
Multiscale approaches to protein-mediated interactions between membranes—relating microscopic and macroscopic dynamics in radially growing adhesions
Macromolecular complexation leading to coupling of two or more cellular membranes is a
crucial step in a number of biological functions of the cell. While other mechanisms may also …
crucial step in a number of biological functions of the cell. While other mechanisms may also …
Theory and simulations of adhesion receptor dimerization on membrane surfaces
The equilibrium constants of trans and cis dimerization of membrane bound (2D) and freely
moving (3D) adhesion receptors are expressed and compared using elementary statistical …
moving (3D) adhesion receptors are expressed and compared using elementary statistical …
Protein induced lipid demixing in homogeneous membranes
Specific lipid environments are necessary for the establishment of protein signaling
platforms in membranes, yet their origin has been highly debated. We present a continuum …
platforms in membranes, yet their origin has been highly debated. We present a continuum …