Medulloblastoma, a malignant brain tumour primarily diagnosed during childhood, has
recently been the focus of intensive molecular profiling efforts, profoundly advancing our …

Brain tumors remain one of the most difficult tumors to treat and, depending on the
diagnosis, have a poor prognosis. Of brain tumors, glioblastoma (GBM) is the most common …

MYC-driven medulloblastomas (MB) are highly aggressive pediatric brain tumors with poor
outcomes, and effective therapies remain limited despite intensive multimodal treatments …

Research on human cerebellar development and disease has been hampered by the need
for a human cell-based system that recapitulates the human cerebellum's cellular diversity …

Medulloblastoma (MB) is the most common malignant childhood brain tumour,, yet the origin
of the most aggressive subgroup-3 form remains elusive, impeding development of effective …

Progenitor heterogeneity and identities underlying tumor initiation and relapse in
medulloblastomas remain elusive. Utilizing single-cell transcriptomic analysis, we …

The cerebellum is one of the best studied parts of the brain. The cerebellar cortex is
composed of four main types of neurons: granule cells, Purkinje cells, and two types of …

Most lncRNAs display species-specific expression patterns suggesting that animal models
of cancer may only incompletely recapitulate the regulatory crosstalk between lncRNAs and …

The primary cilium, a signaling organelle projecting from the surface of a cell, controls
cellular physiology and behavior. The presence or absence of primary cilia is a distinctive …

Abstract Purpose of Review Review recent advances in the understanding of pediatric
medulloblastoma including etiology, biology, radiology, and management of pediatric …