Porosity is an important material feature commonly employed in implants and tissue
scaffolds. The presence of material voids permits the infiltration of cells, mechanical …

Chronically implanted recording electrode arrays linked to prosthetics have the potential to
make positive impacts on patients suffering from full or partial paralysis. Such arrays are …

Transplantation of donor-derived islets into the liver is a successful cellular replacement
therapy for individuals with diabetes. However, the hepatic vasculature is not an optimal …

▪ Abstract Since its inception just over a half century ago, the field of biomaterials has seen a
consistent growth with a steady introduction of new ideas and productive branches. This …

The human body is endowed with an uncanny ability to distinguish self from foreign. The
implantation of a foreign object inside a mammalian host activates complex signaling …

Diabetes mellitus is a worldwide epidemic characterized by chronic hyperglycemia that
results from either a deficiency or tolerance in insulin. 1 In the United States, 8.3% of the …

The current status of sensors capable of continuous measurement of analytes in biological
media is reviewed. This review containing 173 references deals with devices whose use in …

The genesis of the biosensor undoubtedly began with the efforts of Leland C. Clark, Jr. to
measure oxygen in biological fluids. 1 The key innovation was the placement of both the …

The deleterious effect that biofouling has on sensor stability is a serious impediment to the
development of long term implanted biosensors. This paper reviews the surface modification …

The development of implantable biosensors for continuous monitoring of metabolites is an
area of sustained scientific and technological interests. On the other hand, nanotechnology …