Mesenchymal stromal cells in hepatic fibrosis/cirrhosis: from pathogenesis to treatment

X Yang, Q Li, W Liu, C Zong, L Wei, Y Shi… - Cellular & Molecular …, 2023 - nature.com
Hepatic fibrosis/cirrhosis is a significant health burden worldwide, resulting in liver failure or
hepatocellular carcinoma (HCC) and accounting for many deaths each year. The …

Pathogenesis of liver cirrhosis

WC Zhou, QB Zhang, L Qiao - World journal of …, 2014 - pmc.ncbi.nlm.nih.gov
Liver cirrhosis is the final pathological result of various chronic liver diseases, and fibrosis is
the precursor of cirrhosis. Many types of cells, cytokines and miRNAs are involved in the …

Human umbilical cord mesenchymal stem cells: a new era for stem cell therapy

DC Ding, YH Chang, WC Shyu, SZ Lin - Cell transplantation, 2015 - journals.sagepub.com
The human umbilical cord is a promising source of mesenchymal stem cells (HUCMSCs).
Unlike bone marrow stem cells, HUCMSCs have a painless collection procedure and faster …

Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis

T Li, Y Yan, B Wang, H Qian, X Zhang… - Stem cells and …, 2013 - liebertpub.com
Mesenchymal stem cells (MSCs) have been considered as an attractive tool for the therapy
of diseases. Exosomes excreted from MSCs can reduce myocardial ischemia/reperfusion …

Human mesenchymal stem cell transfusion is safe and improves liver function in acute-on-chronic liver failure patients

M Shi, Z Zhang, R Xu, H Lin, J Fu, Z Zou… - Stem cells …, 2012 - academic.oup.com
Acute-on-chronic liver failure (ACLF) is a severe, life-threatening complication, and new and
efficient therapeutic strategies for liver failure are urgently needed. Mesenchymal stem cell …

Human umbilical cord mesenchymal stem cells improve liver function and ascites in decompensated liver cirrhosis patients

Z Zhang, H Lin, M Shi, R Xu, J Fu, J Lv… - Journal of …, 2012 - Wiley Online Library
Decompensated liver cirrhosis (LC), a life‐threatening complication of chronic liver disease,
is one of the major indications for liver transplantation. Recently, mesenchymal stem cell …

Characteristics and clinical applications of Wharton's jelly-derived mesenchymal stromal cells

LL Liau, BHI Ruszymah, MH Ng, JX Law - Current research in translational …, 2020 - Elsevier
Mesenchymal stromal cells (MSCs) are widely used in the clinic because they involve fewer
ethical issues and safety concerns compared to other stem cells such as embryonic stem …

Therapeutic potential of mesenchymal stem cells in regenerative medicine

DM Patel, J Shah, AS Srivastava - Stem cells international, 2013 - Wiley Online Library
Mesenchymal stem cells (MSCs) are stromal cells that have the ability to self‐renew and
also exhibit multilineage differentiation into both mesenchymal and nonmesenchymal …

Mesenchymal stem cell therapy for liver disease: full of chances and challenges

X Yang, Y Meng, Z Han, F Ye, L Wei, C Zong - Cell & bioscience, 2020 - Springer
Liver disease is a major health problem that endangers human health worldwide. Currently,
whole organ allograft transplantation is the gold standard for the treatment of end-stage liver …

Human hepatocyte transplantation: current experience and future challenges

A Dhawan, J Puppi, RD Hughes, RR Mitry - … reviews Gastroenterology & …, 2010 - nature.com
Hepatocyte transplantation has shown potential as an additional treatment modality for
certain diseases of the liver. To date, patients with liver-based metabolic disorders or acute …