The future of peptide‐based drugs
The suite of currently used drugs can be divided into two categories–traditional 'small
molecule'drugs with typical molecular weights of< 500 Da but with oral bioavailability, and …
molecule'drugs with typical molecular weights of< 500 Da but with oral bioavailability, and …
Toll-like receptor 4 (TLR4) inhibitors: Current research and prospective
Y Zhang, X Liang, X Bao, W **ao, G Chen - European journal of medicinal …, 2022 - Elsevier
Abstract Toll-like receptor 4 (TLR4), a member of the Toll-like receptor (TLR) family, is
involved in innate immunity and mediates inflammatory responses by recognizing …
involved in innate immunity and mediates inflammatory responses by recognizing …
Bioactive peptides and protein hydrolysates: research trends and challenges for application as nutraceuticals and functional food ingredients
ECY Li-Chan - Current Opinion in Food Science, 2015 - Elsevier
Highlights•Systematic design of experiments to optimize bioactive peptide
production.•Empirical and bioinformatics complementary approaches to bioactive peptide …
production.•Empirical and bioinformatics complementary approaches to bioactive peptide …
Molecular assembly of Schiff base interactions: construction and application
Y Jia, J Li - Chemical reviews, 2015 - ACS Publications
Controlled fabrication of nanosystems is essential in current science and technology. 1 One
of the most successful strategies for constructing such nanosystems is preparation of …
of the most successful strategies for constructing such nanosystems is preparation of …
Modulators of protein–protein interactions
Since Hedin's characterization of trypsin and antitrypsin in 1906,(1) arguably the first
account of a regulatory protein–protein interaction (PPI), contemporary understanding of …
account of a regulatory protein–protein interaction (PPI), contemporary understanding of …
[HTML][HTML] Turning chiral peptides into a racemic supraparticle to induce the self-degradation of MDM2
Introduction Chirality is immanent in nature, and chiral molecules can achieve their
pharmacological action through chiral matching with biomolecules and molecular …
pharmacological action through chiral matching with biomolecules and molecular …
Site-Selective C(sp3)–H Functionalization of Di-, Tri-, and Tetrapeptides at the N-Terminus
Although the syntheses of novel and diverse peptides rely mainly on traditional coupling
using unnatural amino acids, postsynthetic modification of peptides could provide a …
using unnatural amino acids, postsynthetic modification of peptides could provide a …
ATR-FTIR spectroscopy as a tool to probe surface adsorption on nanoparticles at the liquid–solid interface in environmentally and biologically relevant media
Given the importance of nanoparticle surface composition in nanotoxicology, analytical tools
that can probe nanoparticle surfaces in aqueous media are crucial but remain limited …
that can probe nanoparticle surfaces in aqueous media are crucial but remain limited …
Rosetta FlexPepDock ab-initio: Simultaneous Folding, Docking and Refinement of Peptides onto Their Receptors
Flexible peptides that fold upon binding to another protein molecule mediate a large number
of regulatory interactions in the living cell and may provide highly specific recognition …
of regulatory interactions in the living cell and may provide highly specific recognition …
Druggable protein–protein interactions–from hot spots to hot segments
Highlights•PPIs that are dominated by a continuous epitope are amenable for inhibition.•A
significant share of PPIs contains such 'hot segments'.•Peptide-based inhibitors are obvious …
significant share of PPIs contains such 'hot segments'.•Peptide-based inhibitors are obvious …