CAR T cell-based immunotherapy and radiation therapy: potential, promises and risks

L Hovhannisyan, C Riether, DM Aebersold, M Medová… - Molecular cancer, 2023 - Springer
CAR T cell-based therapies have revolutionized the treatment of hematological
malignancies such as leukemia and lymphoma within the last years. In contrast to the …

Cell Therapies for Acute Radiation Syndrome

BA Christy, MC Herzig, X Wu… - International journal of …, 2024 - mdpi.com
The risks of severe ionizing radiation exposure are increasing due to the involvement of
nuclear powers in combat operations, the increasing use of nuclear power, and the …

Mesenchymal stromal cells surface engineering for efficient hematopoietic reconstitution

H Li, L Ma, N Zhu, X Liang, X Tian, K Liu, X Fu, X Wang… - Biomaterials, 2025 - Elsevier
Mesenchymal stromal cells (MSCs) are believed to migrate to injury sites, release chemical
attractants, and either recruit local stem cells or modulate the immune system positively …

Therapeutic potential of human immature dental pulp stem cells observed in mouse model for acquired aplastic anemia

VF Gonzaga, CV Wenceslau, DP Vieira, BO Policiquio… - Cells, 2022 - mdpi.com
Aplastic anemia (AA) is a rare and serious disorder of hematopoietic stem cells (HSCs) that
results in the loss of blood cells due to the failure of the bone marrow (BM). Although BM …

Dichotomic Potency of IFNγ Licensed Allogeneic Mesenchymal Stromal Cells in Animal Models of Acute Radiation Syndrome and Graft Versus Host Disease

R Chinnadurai, PD Bates, KA Kunugi… - Frontiers in …, 2021 - frontiersin.org
Mesenchymal stromal cells (MSCs) are being tested as a cell therapy in clinical trials for
dozens of inflammatory disorders, with varying levels of efficacy reported. Suitable and …

The role of MSCs and cell fusion in tissue regeneration

J Dörnen, T Dittmar - International Journal of Molecular Sciences, 2021 - mdpi.com
Regenerative medicine is concerned with the investigation of therapeutic agents that can be
used to promote the process of regeneration after injury or in different diseases …

Pre-administration of PLX-R18 cells protects mice from radiation-induced hematopoietic failure and lethality

VP Kumar, S Biswas, GP Holmes-Hampton, M Sheleg… - Genes, 2022 - mdpi.com
Acute Radiation Syndrome (ARS) is a syndrome involving damage to multiple organs
caused by exposure to a high dose of ionizing radiation over a short period of time; even low …

Delayed effects of radiation in adipose tissue reflect progenitor damage and not cellular senescence

AD Ruggiero, MA Davis, AT Davis, D DeStephanis… - Geroscience, 2023 - Springer
The pathogenesis of many age-related diseases is linked to cellular senescence, a state of
inflammation-inducing, irreversible cell cycle arrest. The consequences and mechanisms of …

Donor-Recipient Chimeric Cell Transplantation as the Bridging Therapy for Mitigating Total Body Irradiation-Induced Injury

M Siemionow, K Bieda, K Stawarz, M Cyran… - Stem Cells and …, 2024 - liebertpub.com
In recent years, cell-based therapies have emerged as a promising approach for mitigating
radiation-induced injury. Acute radiation syndrome (ARS) results from exposure to high …

The therapeutic application of stem cells and their derived exosomes in the treatment of radiation-induced skin injury

P Yang, S Zhang, T Yan, F Li… - Radiation Research, 2023 - meridian.allenpress.com
Radiation-induced skin injury (RISI) is a serious concern for nuclear accidents and cancer
radiotherapy, which seriously affects the quality of life of patients. This injury differs from …