CAR T cell-based immunotherapy and radiation therapy: potential, promises and risks
CAR T cell-based therapies have revolutionized the treatment of hematological
malignancies such as leukemia and lymphoma within the last years. In contrast to the …
malignancies such as leukemia and lymphoma within the last years. In contrast to the …
Cell Therapies for Acute Radiation Syndrome
The risks of severe ionizing radiation exposure are increasing due to the involvement of
nuclear powers in combat operations, the increasing use of nuclear power, and the …
nuclear powers in combat operations, the increasing use of nuclear power, and the …
Mesenchymal stromal cells surface engineering for efficient hematopoietic reconstitution
H Li, L Ma, N Zhu, X Liang, X Tian, K Liu, X Fu, X Wang… - Biomaterials, 2025 - Elsevier
Mesenchymal stromal cells (MSCs) are believed to migrate to injury sites, release chemical
attractants, and either recruit local stem cells or modulate the immune system positively …
attractants, and either recruit local stem cells or modulate the immune system positively …
Therapeutic potential of human immature dental pulp stem cells observed in mouse model for acquired aplastic anemia
VF Gonzaga, CV Wenceslau, DP Vieira, BO Policiquio… - Cells, 2022 - mdpi.com
Aplastic anemia (AA) is a rare and serious disorder of hematopoietic stem cells (HSCs) that
results in the loss of blood cells due to the failure of the bone marrow (BM). Although BM …
results in the loss of blood cells due to the failure of the bone marrow (BM). Although BM …
Dichotomic Potency of IFNγ Licensed Allogeneic Mesenchymal Stromal Cells in Animal Models of Acute Radiation Syndrome and Graft Versus Host Disease
R Chinnadurai, PD Bates, KA Kunugi… - Frontiers in …, 2021 - frontiersin.org
Mesenchymal stromal cells (MSCs) are being tested as a cell therapy in clinical trials for
dozens of inflammatory disorders, with varying levels of efficacy reported. Suitable and …
dozens of inflammatory disorders, with varying levels of efficacy reported. Suitable and …
The role of MSCs and cell fusion in tissue regeneration
J Dörnen, T Dittmar - International Journal of Molecular Sciences, 2021 - mdpi.com
Regenerative medicine is concerned with the investigation of therapeutic agents that can be
used to promote the process of regeneration after injury or in different diseases …
used to promote the process of regeneration after injury or in different diseases …
Pre-administration of PLX-R18 cells protects mice from radiation-induced hematopoietic failure and lethality
Acute Radiation Syndrome (ARS) is a syndrome involving damage to multiple organs
caused by exposure to a high dose of ionizing radiation over a short period of time; even low …
caused by exposure to a high dose of ionizing radiation over a short period of time; even low …
Delayed effects of radiation in adipose tissue reflect progenitor damage and not cellular senescence
AD Ruggiero, MA Davis, AT Davis, D DeStephanis… - Geroscience, 2023 - Springer
The pathogenesis of many age-related diseases is linked to cellular senescence, a state of
inflammation-inducing, irreversible cell cycle arrest. The consequences and mechanisms of …
inflammation-inducing, irreversible cell cycle arrest. The consequences and mechanisms of …
Donor-Recipient Chimeric Cell Transplantation as the Bridging Therapy for Mitigating Total Body Irradiation-Induced Injury
M Siemionow, K Bieda, K Stawarz, M Cyran… - Stem Cells and …, 2024 - liebertpub.com
In recent years, cell-based therapies have emerged as a promising approach for mitigating
radiation-induced injury. Acute radiation syndrome (ARS) results from exposure to high …
radiation-induced injury. Acute radiation syndrome (ARS) results from exposure to high …
The therapeutic application of stem cells and their derived exosomes in the treatment of radiation-induced skin injury
P Yang, S Zhang, T Yan, F Li… - Radiation Research, 2023 - meridian.allenpress.com
Radiation-induced skin injury (RISI) is a serious concern for nuclear accidents and cancer
radiotherapy, which seriously affects the quality of life of patients. This injury differs from …
radiotherapy, which seriously affects the quality of life of patients. This injury differs from …