Large biobank-scale whole genome sequencing (WGS) studies are rapidly identifying a
multitude of coding and non-coding variants. They provide an unprecedented resource for …

Non-coding genetic variants outside of protein-coding genome regions play an important
role in genetic and epigenetic regulation. It has become increasingly important to …

Interpreting the molecular mechanism of genomic variations and their causal relationship
with diseases/traits are important and challenging problems in the human genetic study. To …

Background Colorectal cancer (CRC) poses a global health threat, with the oral microbiome
increasingly implicated in its pathogenesis. This study leverages Mendelian Randomization …

Background The progress of genome‐wide association studies (GWAS) in childhood obesity
and its indicators is challenging and there are differences in genetic studies in children and …

Deciphering the fine-scale molecular mechanisms that shape the genetic effects at disease-
associated loci from genome-wide association studies (GWAS) remains challenging. The …

Despite the high prevalence of snoring in Asia, little is known about the genetic etiology of
snoring and its causal relationships with cardiometabolic traits. Based on 100,626 Chinese …

The Reference Human Genome remains the single most important resource for map**
genetic variations and assessing their impact. However, it is monophasic, incomplete and …

Comprehensive expression quantitative trait loci studies have been instrumental for
understanding tissue-specific gene regulation and pinpointing functional genes for disease …

Background The gut mycobiome is closely linked to health and disease; however, its role in
the progression of type 2 diabetes mellitus (T2DM) remains obscure. Here, a multi-omics …