Eukaryotic cells have developed complex systems to regulate the production and response
to reactive oxygen species (ROS). Different ROS control diverse aspects of cell behaviour …

Normal cells explore multiple states to survive stresses encountered during development
and self-renewal as well as environmental stresses such as starvation, DNA damage, toxins …

Contingent upon concentration, reactive oxygen species (ROS) influence cancer evolution
in apparently contradictory ways, either initiating/stimulating tumorigenesis and supporting …

The major concept of" oxidative stress" is an excess elevated level of reactive oxygen
species (ROS) which are generated from vigorous metabolism and consumption of oxygen …

Metastasis is the most complex and deadly event. Tumor-stromal interface is a place where
invasion of tumor cells in the form of single-cell or collective migration occurs, with the latter …

Persistent cancer cells are the discrete and usually undetected cells that survive cancer drug
treatment and constitute a major cause of treatment failure. These cells are characterized by …

Circulating tumor cells (CTC) are shed by cancer into the bloodstream, where a viable
subset overcomes oxidative stress to initiate metastasis. We show that single CTCs from …

Ca2+, a ubiquitous but nuanced modulator of cellular physiology, is meticulously controlled
intracellularly. However, intracellular Ca2+ regulation, such as mitochondrial Ca2+ buffering …

Pancreatic cancer is a disease with limited therapeutic options. Resistance to
chemotherapies poses a significant clinical challenge for patients with pancreatic cancer …

Ca 2+ ions are key second messengers in both excitable and non-excitable cells. Owing to
the rather pleiotropic nature of Ca 2+ transporters and other Ca 2+-binding proteins …