Clinical and laboratory studies over recent decades have established branched evolution as
a feature of cancer. However, while grounded in somatic selection, several lines of evidence …

DNA damage is a threat to genome integrity and can be a cause of many human diseases,
owing to either changes in the chemical structure of DNA or conversion of the damage into a …

Starting from the zygote, all cells in the human body continuously acquire mutations.
Mutations shared between different cells imply a common progenitor and are thus naturally …

Intra-tumor heterogeneity (ITH) is a mechanism of therapeutic resistance and therefore an
important clinical challenge. However, the extent, origin, and drivers of ITH across cancer …

Background The collective of somatic mutations in a genome represents a record of
mutational processes that have been operative in a cell. These processes can be …

Therapy-related myeloid neoplasms (t-MN) arise as a complication of chemo-and/or
radiotherapy. Although t-MN can occur both in adult and childhood cancer survivors, the …

Cell cycle checkpoints secure ordered progression from one cell cycle phase to the next.
They are important to signal cell stress and DNA lesions and to stop cell cycle progression …

DNA base damage is a major source of oncogenic mutations and disruption to gene
expression. The stalling of RNA polymerase II (RNAP) at sites of DNA damage and the …

Despite years of active research into the role of DNA repair and replication in mutagenesis,
surprisingly little is known about the origin of spontaneous human mutation in the germ line …

Genetic instability is a major concern for successful application of stem cells in regenerative
medicine. However, the mutational consequences of the most applied stem cell therapy in …