EMT transition states during tumor progression and metastasis
Epithelial–mesenchymal transition (EMT) is a process in which epithelial cells acquire
mesenchymal features. In cancer, EMT is associated with tumor initiation, invasion …
mesenchymal features. In cancer, EMT is associated with tumor initiation, invasion …
Hybrid epithelial/mesenchymal phenotypes promote metastasis and therapy resistance across carcinomas
Cancer metastasis and therapy resistance are the major unsolved clinical challenges, and
account for nearly all cancer-related deaths. Both metastasis and therapy resistance are …
account for nearly all cancer-related deaths. Both metastasis and therapy resistance are …
Defining heritability, plasticity, and transition dynamics of cellular phenotypes in somatic evolution
Single-cell sequencing has characterized cell state heterogeneity across diverse healthy
and malignant tissues. However, the plasticity or heritability of these cell states remains …
and malignant tissues. However, the plasticity or heritability of these cell states remains …
Partial EMT in head and neck cancer biology: a spectrum instead of a switch
Our understanding of epithelial-to-mesenchymal transition (EMT) has slowly evolved from a
simple two state, binary model to a multi-step, dynamic continuum of epithelial-to …
simple two state, binary model to a multi-step, dynamic continuum of epithelial-to …
Map** lung cancer epithelial-mesenchymal transition states and trajectories with single-cell resolution
Elucidating the spectrum of epithelial-mesenchymal transition (EMT) and mesenchymal-
epithelial transition (MET) states in clinical samples promises insights on cancer progression …
epithelial transition (MET) states in clinical samples promises insights on cancer progression …
[HTML][HTML] Hypoxia, partial EMT and collective migration: Emerging culprits in metastasis
Epithelial-mesenchymal transition (EMT) is a cellular biological process involved in
migration of primary cancer cells to secondary sites facilitating metastasis. Besides, EMT …
migration of primary cancer cells to secondary sites facilitating metastasis. Besides, EMT …
[HTML][HTML] Tumor‑released lncRNA H19 promotes gefitinib resistance via packaging into exosomes in non‑small cell lung cancer
Y Lei, W Guo, B Chen, L Chen… - Oncology …, 2018 - spandidos-publications.com
Currently, resistance to tyrosine kinase inhibitors, such as gefitinib, has become one major
obstacle for improving the clinical outcome of patients with metastatic and advanced‑stage …
obstacle for improving the clinical outcome of patients with metastatic and advanced‑stage …
Hybrid epithelial/mesenchymal phenotype (s): The 'fittest'for metastasis?
Metastasis is the leading cause of mortality among cancer patients. Dissemination enabled
by an epithelial-to-mesenchymal transition (EMT) of carcinoma cells has long been …
by an epithelial-to-mesenchymal transition (EMT) of carcinoma cells has long been …
Emerging concepts of hybrid epithelial-to-mesenchymal transition in cancer progression
Epithelial mesenchymal transition (EMT) is a complex process through which epithelial (E)
cells lose their adherens junctions, transform into mesenchymal (M) cells and attain motility …
cells lose their adherens junctions, transform into mesenchymal (M) cells and attain motility …
Hybrid epithelial/mesenchymal state in cancer metastasis: clinical significance and regulatory mechanisms
TT Liao, MH Yang - Cells, 2020 - mdpi.com
Epithelial-mesenchymal transition (EMT) has been well recognized for its essential role in
cancer progression as well as normal tissue development. In cancer cells, activation of EMT …
cancer progression as well as normal tissue development. In cancer cells, activation of EMT …