This review serves as a systematic guide to the genetics of generalized anxiety disorder
(GAD) and further focuses on anxiety-relevant endophenotypes, such as pathological worry …

Decreased serotonergic activity has been implicated in anxiety and major depression, and
antidepressants directly or indirectly increase the long-term activity of the serotonin system …

Generalized anxiety disorder (GAD) is a prevalent and highly disabling mental health
condition; however, there is still much to learn with regard to pertinent biomarkers, as well as …

Abstract Rationale Serotonin (5-HT) neurotransmission is intimately linked to anxiety and
depression and a diverse body of evidence supports the involvement of the main inhibitory …

Objectives: Biomarkers are defined as anatomical, biochemical or physiological traits that
are specific to certain disorders or syndromes. The objective of this paper is to summarise …

Generalized anxiety disorder (GAD) is relatively common, with lifetime prevalence rates of 4-
7%. It is a disorder of chronic uncontrollable worry, compounded by physiological symptoms …

The serotonin-1A (5-HT1A) receptor is an abundant post-synaptic 5-HT receptor
(heteroreceptor) implicated in regulation of mood, emotion and stress responses and is the …

Over 20 years ago, Deakin and Graeff hypothesized about the role of different serotonergic
pathways in controlling the behavioral and physiologic responses to aversive stimuli, and …

The impact of the COVID-19 pandemic on clinically stable older patients with psychiatric
disorders is unclear. This study examined the prevalence of depressive and anxiety …

The serotonin 1A receptor gene (HTR1A) has been associated with mood disorders (MDs),
including major depressive disorder (MDD) and bipolar disorder (BP). Therefore, we …