Toxoplasma gondii infection and its implications within the central nervous system

SK Matta, N Rinkenberger, IR Dunay… - Nature Reviews …, 2021 - nature.com
Toxoplasma gondii is a parasite that infects a wide range of animals and causes zoonotic
infections in humans. Although it normally only results in mild illness in healthy individuals …

Venn diagrams in bioinformatics

A Jia, L Xu, Y Wang - Briefings in bioinformatics, 2021 - academic.oup.com
Venn diagrams are widely used tools for graphical depiction of the unions, intersections and
distinctions among multiple datasets, and a large number of programs have been developed …

[HTML][HTML] Microscopic examination of spatial transcriptome using Seq-Scope

CS Cho, J **, Y Si, SR Park, JE Hsu, M Kim, G Jun… - Cell, 2021 - cell.com
Spatial barcoding technologies have the potential to reveal histological details of
transcriptomic profiles; however, they are currently limited by their low resolution. Here, we …

EVenn: Easy to create repeatable and editable Venn diagrams and Venn networks online

T Chen, H Zhang, Y Liu, YX Liu… - Journal of genetics …, 2021 - pubmed.ncbi.nlm.nih.gov
EVenn: Easy to create repeatable and editable Venn diagrams and Venn networks online
EVenn: Easy to create repeatable and editable Venn diagrams and Venn networks online J …

[HTML][HTML] An epigenetic barrier sets the timing of human neuronal maturation

G Ciceri, A Baggiolini, HS Cho, M Kshirsagar… - Nature, 2024 - nature.com
The pace of human brain development is highly protracted compared with most other
species,,,,,–. The maturation of cortical neurons is particularly slow, taking months to years to …

A phase II study of talazoparib monotherapy in patients with wild-type BRCA1 and BRCA2 with a mutation in other homologous recombination genes

JJ Gruber, A Afghahi, K Timms, A DeWees, W Gross… - Nature Cancer, 2022 - nature.com
Talazoparib, a PARP inhibitor, is active in germline BRCA1 and BRCA2 (g BRCA1/2)-mutant
advanced breast cancer, but its activity beyond g BRCA1/2 is poorly understood. We …

Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia

MB Pappalardi, K Keenan, M Cockerill, WA Kellner… - Nature cancer, 2021 - nature.com
DNA methylation, a key epigenetic driver of transcriptional silencing, is universally
dysregulated in cancer. Reversal of DNA methylation by hypomethylating agents, such as …

The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles

AM Leidal, HH Huang, T Marsh, T Solvik, D Zhang… - Nature cell …, 2020 - nature.com
Traditionally viewed as an autodigestive pathway, autophagy also facilitates cellular
secretion; however, the mechanisms underlying these processes remain unclear. Here, we …

Secretory autophagy maintains proteostasis upon lysosome inhibition

TA Solvik, TA Nguyen, YH Tony Lin, T Marsh… - Journal of Cell …, 2022 - rupress.org
The endolysosome system plays central roles in both autophagic degradation and secretory
pathways, including the release of extracellular vesicles and particles (EVPs). Although …

Site-specific development and progressive maturation of human tissue-resident memory T cells over infancy and childhood

TJ Connors, R Matsumoto, S Verma, PA Szabo… - Immunity, 2023 - cell.com
Infancy and childhood are critical life stages for generating immune memory to protect
against pathogens; however, the timing, location, and pathways for memory development in …