Lung cancer is the most often diagnosed cancer in the world and the most frequent cause of
cancer death. The prognosis for lung cancer is relatively poor and 75% of patients are …

Cancer cells are shaped through an evolutionary process of DNA mutation, cell selection
and population expansion. Early steps in this process are driven by a set of mutated driver …

Lung cancer is the number one cause of cancer-related deaths. The malignancy is
characterized by dismal prognosis and poor clinical outcome mostly due to advanced-stage …

Lung cancer is the leading cause of cancer-related deaths worldwide. Non-small cell lung
cancer (NSCLC) represents the most frequently diagnosed subtype of this morbid …

Ductal carcinoma in situ (DCIS) is the most frequently diagnosed early‐stage breast cancer.
Only a subset of patients progress to invasive ductal carcinoma (IDC), and this presents a …

Background The absence of the putative DNA/RNA helicase Schlafen11 (SLFN11) is
thought to cause resistance to DNA-damaging agents (DDAs) and PARP inhibitors. Methods …

Background Reinvigoration of T-cell exhaustion with antibodies has shown promising
efficacy in patients with non-small-cell lung cancer (NSCLC). However, the characteristics of …

Mosaicism, the presence of subpopulations of cells bearing somatic mutations, is associated
with disease and aging and has been detected in diverse tissues, including apparently …

Lung adenocarcinoma (LUAD) is the most common and aggressive subtype of lung cancer
with the greatest heterogeneity and aggression. Inspite of recent years' achievements in …

Recent advances in bulk sequencing approaches as well as genomic decoding at the single-
cell level have revealed surprisingly high somatic mutational burdens in normal tissues, as …