Astrocytes contribute to the complex cellular pathology of Alzheimer's disease (AD).
Neurons and astrocytes function in close collaboration through neurotransmitter recycling …

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in ageing,
affecting around 46 million people worldwide but few treatments are currently available. The …

Reactive astrocytes play an important role in neurological diseases, but their molecular and
functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal …

β-amyloid (Aβ)–dependent neuronal hyperactivity is believed to contribute to the circuit
dysfunction that characterizes the early stages of Alzheimer's disease (AD). Although …

Importance Network hyperexcitability may contribute to cognitive dysfunction in patients with
Alzheimer disease (AD). Objective To determine the ability of the antiseizure drug …

Globally, as populations age there will be challenges and opportunities to deliver optimal
health care to senior citizens. Epilepsy, a condition characterised by spontaneous recurrent …

Our incomplete understanding of the link between Alzheimer's Disease pathology and
symptomatology is a crucial obstacle for therapeutic success. Recently, translational studies …

Since it was first generally accepted that the two amino acids glutamate and GABA act as
principal neurotransmitters, several landmark discoveries relating to this function have been …

The function of neural circuits and networks can be controlled, in part, by modulating the
synchrony of their components' activities. Network hypersynchrony and altered oscillatory …

Alzheimer disease (AD) is a frequent and devastating neurodegenerative disease in
humans, but still no curative treatment has been developed. Although many explicative …