Longitudinal clinical–pathological studies have increasingly recognized the importance of
mixed pathologies (the coexistence of one or more neurodegenerative and cerebrovascular …

Age, apolipoprotein E ε4 (APOE) and chromosomal sex are well-established risk factors for
late-onset Alzheimer's disease (LOAD; AD). Over 60% of persons with AD harbor at least …

Abstract Characterization of the genetic landscape of Alzheimer's disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …

Aggregated insoluble tau is one of two defining features of Alzheimer's disease. Because
clinical symptoms are strongly correlated with tau aggregates, drug development and …

Vascular contributions to dementia and Alzheimer's disease are increasingly recognized,,,,–.
Recent studies have suggested that breakdown of the blood–brain barrier (BBB) is an early …

Background The order and magnitude of pathologic processes in Alzheimer's disease are
not well understood, partly because the disease develops over many years. Autosomal …

The blood-brain barrier (BBB) limits entry of blood-derived products, pathogens, and cells
into the brain that is essential for normal neuronal functioning and information processing …

Alzheimer's disease (AD) pathology is thought to progress from normal cognition through
preclinical disease and ultimately to symptomatic AD with cognitive impairment. Recent work …

ABSTRACT OASIS-3 is a compilation of MRI and PET imaging and related clinical data for
1098 participants who were collected across several ongoing studies in the Washington …

Several autopsy studies recognize the locus coeruleus (LC) as the initial site of
hyperphosphorylated TAU aggregation, and as the number of LC neurons harboring TAU …