Longevity, ie, the property of being long-lived, has its natural limitation in the aging process.
Longevity has a strong genetic component, as has become apparent from studies with a …

Ubiquinone (UQ, coenzyme Q) is an essential electron transfer lipid in the mitochondrial
respiratory chain. It is a main source of mitochondrial reactive oxygen species (ROS) but …

Mitochondrial dysfunction is a hallmark of skeletal muscle degeneration during aging. One
mechanism through which mitochondrial dysfunction can be caused is through changes in …

On the basis of the free radical and rate of living theories of aging, it has been proposed that
decreased metabolism leads to increased longevity through a decreased production of …

Aging has long since been ascribed to the gradual accumulation of DNA mutations in the
genome of somatic cells. However, it is only recently that the necessary sophisticated …

Insulin signaling, mitochondrial respiration, and dietary restriction share conserved roles not
only in the regulation of lifespan, but also in the timing and control of diverse functions such …

PPD quinone (6-PPDQ) is extensively existed in various environments. In Caenorhabditis
elegans, exposure to 6-PPDQ could cause multiple toxic effects. In the current study, we …

Abstract The Caenorhabditis elegans mitochondrial (Mit) mutants have disrupted
mitochondrial electron transport chain (ETC) functionality, yet, surprisingly, they are long …

Ubiquinone (UQ), also known as coenzyme Q (CoQ), is a redox-active lipid present in all
cellular membranes where it functions in a variety of cellular processes. The best known …

Coenzyme Q (CoQ), also known as ubiquinone, comprises a benzoquinone head group and
a long isoprenoid sidechain. It is thus extremely hydrophobic and resides in membranes. It is …