Go mediates the coupling of the mu opioid receptor to adenylyl cyclase in cloned neural cells and brain.

BD Carter, F Medzihradsky - Proceedings of the National …, 1993 - National Acad Sciences
In membranes from SH-SY5Y human neuroblastoma cells differentiated with retinoic acid,
the mu-selective agonist Tyr-D-Ala-Gly-N-Me-Phe-Gly-ol (DAMGO) inhibited cAMP formation …

[HTML][HTML] Conversion of GDP into GTP by nucleoside diphosphate kinase on the GTP-binding proteins.

S Kikkawa, K Takahashi, N Shimada, M Ui… - Journal of Biological …, 1990 - Elsevier
A direct interaction of alpha beta gamma trimeric GTP binding proteins (G proteins; G0 and
Gs) with nucleoside diphosphate kinase (NDP kinase) was investigated with …

Posttranslational modification of Gαo1 generates Gαo3, an abundant G protein in brain

T Exner, ON Jensen, M Mann… - Proceedings of the …, 1999 - National Acad Sciences
Gαo, the most abundant G protein in mammalian brain, occurs at least in two subforms, ie,
Gαo1 and Gαo2, derived by alternative splicing of the mRNA. A third Gαo1-related isoform …

G-proteins and hormonal inhibition of insulin secretion from HIT-T15 cells and isolated rat islets

ER Seaquist, AR Neal, KD Shoger, TF Walseth… - Diabetes, 1992 - Am Diabetes Assoc
G-proteins are important mediators of hormonal inhibition of insulin secretion. To
characterize the pertussis toxin–sensitive substrates present in HIT cell membranes, we …

Purification of a novel G-protein α0-subtype from mammalian brain

B Nürnberg, K Spicher, R Harhammer… - Biochemical …, 1994 - portlandpress.com
Three distinct G-protein alpha o-subtypes, ie alpha o1, alpha o2 and a newly observed
'alpha o3', are present in membranes of mammalian brain, each appearing as two isoforms …

Subunit interactions of GTP‐binding proteins

H Heithier, M Fröhlich, C Dees… - European journal of …, 1992 - Wiley Online Library
Fluorescence energy transfer [cf. Förster, T.(1948) Ann. Phys. 6, 55–75] was tested for its
suitability to study quantitative interactions of subunits of Go with each other and these …

Heterogeneity of three electrophoretically distinct Go α-subunits in mammalian brain

K Spicher, B Nuernberg, B Jäger, W Rosenthal… - FEBS letters, 1992 - Elsevier
So far three splice variants of the α o-gene coding for two α o proteins have been identified
by molecular cloning, and the corresponding proteins purified. In the present study subtype …

Bovine Brain GO Isoforms Have Distinct γ Subunit Compositions (∗)

MD Wilcox, J Dingus, EA Balcueva, WE McIntire… - Journal of Biological …, 1995 - ASBMB
The γ subunit composition of the major bovine brain GO and G i proteins (G OA, G OB, G OC,
G i1, and G i2) was characterized using antibodies against specific γ isoforms. Each of the …

Structural heterogeneity of membrane receptors and GTP‐binding proteins and its functional consequences for signal transduction

F Boege, E Neumann… - European journal of …, 1991 - Wiley Online Library
Recent information obtained, mainly by recombinant cDNA technology, on structural
heterogeneity of hormone and transmitter receptors, of GTP‐binding proteins (G‐proteins) …

Specific antibodies against Go isoforms reveal the early expression of the Go2 alpha subunit and appearance of Go1 alpha during neuronal differentiation.

B Rouot, N Charpentier, C Chabbert… - Molecular …, 1992 - molpharm.aspetjournals.org
We have previously identified two isoforms of Go alpha in membranes of N1E-115
neuroblastoma cells, using an antibody raised against the purified Go alpha subunit; one …