The basic-helix/loop/helix per-Arnt-sim (bHLH/PAS) family comprises many transcription
factors, found throughout all three kingdoms of life; bHLH/PAS members “sense” …

Traditionally considered as a critical intermediate in the toxic and carcinogenic response to
dioxin (2, 3, 7, 8-tetrachlorodibenzo-p-dioxin, TCDD), the Aryl hydrocarbon/Dioxin receptor …

For decades, the aryl hydrocarbon receptor (AHR) was studied for its role in environmental
chemical toxicity ie, as a quirk of nature and a mediator of unintended consequences of …

The aryl hydrocarbon receptor (AHR) is not essential to survival, but does act as a key
regulator of many normal physiological events. The role of this receptor in toxicological …

The aryl hydrocarbon receptor (AHR) is a pivotal chemical sensor that transduces extrinsic
and intrinsic signals into cellular responses. AHR was originally thought to be involved in not …

The antagonistic pleiotropy hypothesis is a well-known evolutionary theory to explain the
aging process. It proposes that while a particular gene may possess beneficial effects during …

Octamer-binding transcription factor 4 (Oct4), a homeodomain transcription factor, is well
established as a master factor controlling the self-renewal and pluripotency of pluripotent …

Circadian clocks control the internal sleep-wake rhythmicity of 24 h which is synchronized by
the solar cycle. Circadian regulation of metabolism evolved about 2.5 billion years ago, ie …

Background Self-renewing, chemoresistant breast cancer stem cells are believed to
contribute significantly to cancer invasion, migration and patient relapse. Therefore, the …

The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor that responds to
environmental toxicants, is increasingly recognized as a key player in embryogenesis and …